OPG: Research Programs

Population Architecture using Genomics and Epidemiology (PAGE) Consortium

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Background

Genome-wide association studies have identified many genetic variants related to disease and have highlighted the need to further explore initial findings in non-European populations. The Population Architecture using Genomics and Epidemiology (PAGE) Consortium (RFA HG-07-014 and RFA HG-07-015) was formed in July 2008.

PAGE aims to examine putative causal genetic variants across approximately 100,000 African Americans, Asian Americans, American Indians, European Americans, Hispanic Americans, and Native Hawaiians from 4 groups representing 9 large U.S.-based cohorts. By coordinating genotyping and phenotype harmonization across groups, PAGE is defining the epidemiological architecture of cross-population allele frequencies, relative risks, and distribution of phenotypes associated with particular variants and their environmental modifiers.

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PAGE Investigators

Map of PAGE Investigators
Study Investigators

    Genetics Epidemiology of Causal Variants Across the Life Course (CALiCo Consortium)

    • Atherosclerosis Risk In Communities (ARIC)
    • Coronary Artery Risk In Young Adults (CARDIA)
    • Cardiovascular Health Study (CHS)
    • Hispanic Community Health Study
    • Strong Heart Cohort Study
    • Strong Heart Family Study

    Principal Investigator (PI): Kari North, Ph.D., University of North Carolina at Chapel Hill

    Epidemiologic Architecture of Genes Linked to Environment (EAGLE)
    Principal Investigator (PI): Dana Crawford, Ph.D., Vanderbilt University, Nashville, Tenn.

    Multiethnic Cohort (MEC)
    Principal Investigator (PI): Loic Le Marchand, M.D., Ph.D., University of Hawaii Cancer Research Center, Honolulu

    Women's Health Initiative (WHI)
    Principal Investigator (PI): Charles Kooperberg, Ph.D., Fred Hutchinson Cancer Research Center, Seattle, Wash.

Coordinating Center
Principal Investigator (PI): Tara C. Matise, Ph.D., Department of Genetics, Rutgers University, New Brunswick, N.J.

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Project Structure

Diagram of project structure
  • The Steering Committee is the governing body for the consortium and is composed of the Principal Investigators from each institution and the NIH Project Scientist.

      • Chair: Jonathan Haines, Ph.D., Vanderbilt University

  • The External Scientific Panel provides input to the NHGRI Director about the progress and direction of the Network.

    Chair: Julie Buring, Sc.D., Harvard University

    • Mercedes Carnethon, Ph.D., Northwestern University
    • Deborah Nickerson, Ph.D., University of Washington
    • Christopher O'Donnell, M.D., National Heart, Lung, and Blood Institute, Harvard Medical School
    • Gloria Petersen, Ph.D., Mayo Clinic


  • PAGE Working Groups address issues related to phenotype harmonization (Diabetes/obesity, CVD, Cancer, Inflammation/autoimmunity, Exposures), SNP Selection and Quality Control, Ethnicity and Ancestry, Data Display and Dissemination and the Metabochip pilot.

  • PAGE Standing Committees coordinate activities related to Statistical Analysis and Publications/Presentations.

  • PAGE Project Groups perform cross-study analyses and write manuscripts. Current Project Groups are focused on cancer, cardiovascular disease, lipids, obesity, type 2 diabetes, menopause/menarche, the Metabochip and phenotype-wide association study (PheWAS).

Study Design, Participant and Genotyping Characteristics of PAGE Cohorts

Cohort Type of Study Focus of Cohort Years Collected Length of Follow-Up Mean Age Description Age Range % Women Genotyping Platforms
EAGLE Cross-sectional N/A 1991-1994,
1999-2002		 N/A 35 12-95 54 Applied Biosystems TaqMan, OpenArrays TaqMan, Sequenom iPlex, Illumina BeadXpress
MEC Nested Case Control Cancer 1993-1998 17 years 60 45-78 55 Applied Biosystems TaqMan, OpenArrays TaqMan
WHI Cohort and Clinical Trials Women's Health 1993-1998 17 years 63 50-79 100 Illumina BeadXpress
CALiCo-ARIC Longitudinal Cardiovascular Disease 1987-2007 20 years 54 45-64 55.1 Applied Biosystems TaqMan
CALiCo-CARDIA Longitudinal Cardiovascular Disease 1986-2006 25 years 25 18-30 54.4 Applied Biosystems TaqMan
CALiCo-CHS Longitudinal Cardiovascular Disease 1988-1999 18 years 73 65-100 57.6 Applied Biosystems TaqMan
CALiCo-SHS Longitudinal Cardiovascular Disease 1988-Present 22 years 40 14-91 59.3 Applied Biosystems TaqMan
CALiCo-HCHS-SOL Longitudinal Cardiovascular Disease 2008-Present 2 years 55 18-72 65 Applied Biosystems TaqMan

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Resources

Population Architecture using Genomics and Epidemiology (PAGE) website

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Published Manuscripts

Published Manuscripts related to Population Architecture using Genomics and Epidemiology (PAGE) New

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Steering Committee Meeting Minutes

PAGE Steering Committee Public Documents [pagestudy.org]

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Contacts

Lucia Hindorff, Ph.D., M.P.H.
Project Scientist
Office of Population Genomics, NHGRI

Heather Junkins, M.S.
Health Science Analyst
Office of Population Genomics, NHGRI

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Last Updated: June 18, 2012