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PrintBenjamin Feldman, Ph.D.
Investigator, Medical Genetics Branch
Head, Vertebrate Embryology Section
Selected Publications
Feldman B., Gates M.A., Egan E., Dougan S.T., Rennebeck G., Sirotkin H.I., Schier A.F. and Talbot W.S. Zebrafish organizer development and germ-layer formation require nodal-related signals. Nature, (6698):181-185. 1998. [PubMed]
Feldman B., Concha M., Saude L., Parsons M.J., Adams R., Wilson S., and Stemple D.L. Lefty antagonism of squint is essential for normal gastrulation. Current Biology, (24);2129-2135. 2002. [PubMed]
Pei W., Williams P. H., Clark M. D., Stemple D. L., Feldman B. Environmental and genetic modifiers of squint penetrance during zebrafish embryogenesis. Developmental Biology, 308(2):368-78. 2007. [PubMed]
Pei W, Noushmehr H, Costa J, Ouspenskaia MV, Elkahloun AG, Feldman B. An early requirement for maternal FoxH1 during zebrafish gastrulation. Dev Biol, 310(1):10-22. 2007. [PubMed]
Roessler E, Ouspenskaia MV, Karkera JD, Vélez JI, Kantipong A, Lacbawan F, Bowers P, Belmont JW, Towbin JA, Goldmuntz E, Feldman B, Muenke M. Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly. Am J Hum Genet, 83:18-29. 2008. [PubMed]
Domené S, Roessler E, El-Jaick KB, Snir M, Brown JL, Vélez JI, Bale S, Lacbawan F, Muenke M, Feldman B. Mutations in the human SIX3 gene in holoprosencephaly are loss of function. Hum Mol Genet, 17:3919-3928. 2008. [PubMed]
Brown JL, Snir M, Noushmehr H, Kirby M, Hong SK, Elkahloun AG, Feldman B. Transcriptional profiling of endogenous germ layer precursor cells identifies dusp4 as an essential gene in zebrafish endoderm specification. Proc Natl Acad Sci U S A., 105(34):12337-42. 2008. [PubMed]
Pei W, Feldman B. Identification of common and unique modifiers of zebrafish midline bifurcation and cyclopia. Dev Biol, 326(1):201-11. 2009. [PubMed]
E. Roessler , W. Pei, M. V. Ouspenskaia , J. D. Karkera ,J. I. Veléz, S. Banerjee- Basu , G. Gibney, P. J. Lupo, L. E. Mitchell, J. A. Towbin, P. Bowers ,J. W. Belmont, E. Goldmuntz, A. D. Baxevanis, B. Feldman, M. Muenke. Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. Molecular Genetics and Metabolism, 98: 225-234. 2009. [PubMed]
S.-K. Hong, C. S. Levin, J. L Brown, H. Wan, B. T. Sherman, d.-W Huang, R. A Lempicki and B. Feldman. Pre-gastrula expression of zebrafish extraembryonic genes. BMC Developmental Biology, 10: 42. 2010. [PubMed]
M. Huizing, H. Dorward, L. Ly, E. Klootwijk, R. Kleta, F. Skovby, W. Pei, B., Feldman, W. A. Gahl and Y. Anikster. OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria. Molecular Genetics and Metabolism, 100:149-54. 2010. [PubMed]
W. Pei, L. E. Kratz, I. Bernardini, R. Sood, T. Yokogawa, H. Dorward, C. Ciccone, R. I. Kelley, Y. Anikster, H. A. Burgess, M. Huizing and B. Feldman. A model for Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3. Development, 137(15):2587-96. 2010. [PubMed]
Hong SK, Jang MK, Brown JL, McBride AA, Feldman B. Embryonic mesoderm and endoderm induction requires the actions of non-embryonic Nodal-related ligands and Mxtx2. Development, 138(4):787-95. 2011. [PubMed]
Last Updated: February 21, 2012
