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Safety and Health Topics: |
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| 4,4'-Methylenedianiline |
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General Description
Synonym(s): MDA, DADPM; DAPM; p,p'-Methylenedianiline; Methylenedianiline; TONOX; HT972; NCI-C54604; Composite Constituent
OSHA IMIS Code Number: 1732
Chemical Abstracts Service (CAS) Registry Number: 101-77-9
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: BY5425000; 8360
Department of Transportation Regulation Number (49 CFR 172.101): UN2651 Keep Away From Food
NIOSH Pocket Guide to Chemical Hazards, 4,4'-Methylenedianiline: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1050 Methylenedianiline -- 10 ppb TWA; 100 ppb STEL; 5 ppb Action Level
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.60 Methylenedianiline -- 10 ppb TWA; 100 ppb STEL; 5 ppb Action Level
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1050 Methylenedianiline requirements identical to 1910.1050
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.1 ppm, 0.81 mg/m3 TWA; Skin; Appendix A3 (Confirmed Animal Carcinogen with Unknown Relevance to Humans)
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): Lowest Feasible Concentration (LFC), Potential Carcinogen
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 2B, possibly carcinogenic to humans
Health Effects: Causes liver, kidney, and spleen damage in experimental animals; hepatitis in humans.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
sampling media: Coated Glass Fiber Filters (37 mm) in 3 piece cassette. Coating is Sulfuric Acid.
maximum volume: 100 Liters maximum flow rate: 1.0 L/min
current analytical method: Gas Chromatography; GC/ECD
method reference: OSHA Manual of Analytical Methods (OSHA 57)
method classification: Fully Validated
note: Within ten hours after sampling, transfer filter to glass vial containing 2 mL deionized water. Filters may be obtained by OSHA personnel from SLTC.
condition: Column 3% OV-101; Inj 235 deg C; Oven 220 deg C; Det 335 deg C; Ret time 3.5 min; DL 0.008 ug/sample.
Wipe sampling: Glass Fiber Filters wetted with 0.6 mL of a 60/40 Methanol/Deionized Water solution. Wipe samples are placed in a solution of 0.07 N H2SO4 for shipment. Solutions of 60/40 Methanol/Deionized Water and 0.07 N H2SO4 are available from SLTC for OSHA staff. Kits for on-site screening of aromatic amines are available from commercial suppliers.
* All Trademarks are the property of their respective owners.
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| Revised: 04 August 2003 |
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