Chemical Sampling Information
	2-Ethoxyethyl acetate
Quick Links General Description Exposure Limits Health Factors Monitoring Search    [use word(s)/phrase] Table of Contents By Name A B C D E F G H I J K L M N O P Q R S T U V W X Y Z By CAS Number General Description Synonyms: Cellosolve® acetate; Cellosolve acetate; EGEEA; Ethylene glycol monoethyl ether acetate; Glycol monoethyl ether acetate OSHA IMIS Code Number: 1037 Chemical Abstracts Service (CAS) Registry Number: 111-15-9 NIOSH, Registry of Toxic Effects (RTECS) Identification Number: KK8225000 Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1172 129 [27 KB, PDF] NIOSH Pocket Guide to Chemical Hazards, 2-Ethoxyethyl acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more Exposure Limits OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 540 mg/m3 TWA; Skin OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 540 mg/m3 TWA; Skin OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 540 mg/m3 TWA; Skin American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 27 mg/m3 TWA; Skin; BEI National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.5 ppm, 2.7 mg/m3 TWA; Skin Health Factors NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 500 ppm Potential symptoms: Irritation of eyes, nose; vomiting; kidney damage; headache, dizziness, drowsiness, paralysis, unconsciousness; in animals: reproductive, teratogenic effects; SKIN ABS; INGES ACUTE: Nausea, vomiting. Health Effects: Irritation-Eyes, Nose, Throat, Skin---Mild (HE16); Cumulative Blood Disturbances (HE12) Reproductive hazards---Teratogenesis and other reproductive impairment (HE5). Affected organs: Eyes, respiratory system, gastrointestinal tract; reproductive system, hematopoietic system. Notes: Explosive vapor/air mixtures of 2-ethoxyethyl acetate may be formed at temperatures above 51°C. Teratogenic effects in rats by inhalation exposure included heart defects and rib malformations. Increased frequencies of visceral and skeletal variants also occurred. A concentration of 600 ppm was lethal to 100% of the offspring of the 9 pregnant rats exposed to this concentration without the dams showing overt toxicity. 2-Ethoxyethyl acetate is rapidly hydrolyzed to 2-ethoxyethanol, which in turn, is metabolized mainly by alcohol dehydrogenase to 2-ethoxyacetaldehyde and further by aldehyde dehydrogenase to 2-ethoxyacetic acid, metabolites which are thought to be involved in some of the toxic effects. Studies of occupational exposure have supported in vitro studies indicating significant systemic absorption of 2-ethoxyethyl acetate through the skin, which measured a mean absorption rate of 0.8 mg per cm2 of human skin per hour. Curve-fitting of 17 occupationally exposed employees for the time course of urinary excretion of the metabolite, 2-ethoxyacetic acid, yielded an excretion half-time of 57 hours, with individual half-times ranging between 25 and 240 hours. Date Last Revised: 09/20/2006 Literature Basis: NIOSH Pocket Guide to Chemical Hazards: 2-Ethoxyethyl acetate. International Chemical Safety Cards (WHO/IPCS/ILO): 2-Ethoxyethyl acetate. MMWR: Criteria for a recommended standard: occupational exposure to ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, and their acetates. Morbidity and mortality weekly report 41(21): 386, 1992. Dugard, P.H., Walker, M., Mawdsley, S.J. and Scott, R.C.: Absorption of some glycol ethers through human skin in vitro. Environ. Health Perspect. 57: 193-197, 1984. Johnson, W., Jr., Cosmetic Ingredient Review Expert Panel: Final report on the safety assessment of ethoxyethanol and ethoxyethanol acetate. Int. J. Toxicol. 21(Suppl. 1): 9-62, 2002. Nelson, B.K., et al.: Comparative inhalation teratogenicity of four glycol ether solvents and an amino derivative in rats. Environ. Health Perspect. 57: 261-271, 1984. Pohanish, R.P. (editor): 2-Ethoxyethyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1037-1039. Söhnlein, B., Letzel, S., Weltle, D., Rüdiger, H.W. and Angerer, J.: Occupational chronic exposure to organic solvents. XIV. Examinations concerning the evaluation of a limit value for 2-ethoxyethanol and 2-ethoxyethyl acetate and the genotoxic effects of these glycol ethers. Int. Arch. Occup. Environ. Health 64(7): 479-484, 1993. Stott, W.T. and McKenna, M.J.: Hydrolysis of several glycol ether acetates and acrylate esters by nasal mucosal carboxylesterase in vitro. Fundam. Appl. Toxicol. 5(2): 399-404, 1985. Zissu, D.: Experimental study of cutaneous tolerance to glycol ethers. Contact Dermatitis 32(2): 74-77, 1995. Monitoring Methods used by OSHA Laboratory Sampling/Analytical Method: sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: (95:5) Methylene Chloride:Methanol maximum volume: 10 Liters   maximum flow rate: 0.1 L/min current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 53) method classification: Fully Validated note: Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory. sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh) analytical solvent: (95:5) Methylene Chloride:Methanol maximum volume: 48 Liters   maximum flow rate: 0.1 L/min (long term) maximum volume: 15 Liters   maximum flow rate: 0.1 L/min (short term) current analytical method: Gas Chromatography; GC/FID method reference: OSHA Analytical Method (OSHA 79) method classification: Fully Validated note: Use these larger maximum volumes to monitor sub-ppm levels. Samples for 2-methoxyethyl acetate and/or for 2-ethoxyethyl acetate should be refrigerated upon receipt at the analytical laboratory. Wipe Sampling Method: sampling media: charcoal pad note: Seal in glass vial for shipment. All Trademarks are the property of their respective owners. Accessibility Assistance: Contact the OSHA Directorate of Science, Technology and Medicine at 202-693-2300 for assistance accessing PDF materials.