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Chemical Sampling Information |
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| Crotonaldehyde |
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General Description
Synonyms: beta-Mehylacrolein; Propylene aldehyde; Crotonic aldehyde; 2-Butenal
OSHA IMIS Code Number: 0770
Chemical Abstracts Service (CAS) Registry Number: 123-73-9
Other Chemical Abstracts Service (CAS) Registry Number: 4170-30-3
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: GP9499000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1143 131P (inhibited)
NIOSH Pocket Guide to Chemical Hazards, Crotonaldehyde: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 2 ppm, 6 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 2 ppm, 6 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 2 ppm, 6 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 0.3 ppm, 0.86 mg/m3 Ceiling; Skin; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 2 ppm, 6 mg/m3 TWA; Appendix C - Supplementary Exposure Limits (Aldehydes)
Health Factors
International Agency for Research on Cancer (IARC) carcinogenic classification: Group 3 - not classifiable as to its carcinogenicity to humans
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 50 ppm
Potential symptoms: Eye, respiratory system irritation; cough, burning sensation, sore throat, labored breathing, pulmonary edema (may be delayed); eye redness, pain, lacrimation, severe deep burns.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Lung edema (HE11)
Affected organs: Respiratory system, eyes, skin
Note: In addition to its various industrial uses, crotonaldehyde is formed in the body as a product of lipid peroxidation and can form adducts with DNA, as well as with lysine and histidine amino acids in proteins.
Date Last Revised: 04/29/2004
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Crotonaldehyde.
- International Chemical Safety Cards (WHO/IPCS/ILO): Crotonaldehyde.
- Ichihashi, K., Osawa, T., Toyokuni, S. and Uchida, K.: Endogenous formation of protein adducts with carcinogenic Aldehydes: implications for oxidative stress. J. Biol. Chem. 276(26): 23903-23913, 2001.
- Pan, J. and Chung, F.L.: Formation of cyclic deoxyguanosine adducts from omega-3 and omega-6 polyunsaturated fatty acids under oxidative conditions. Chem. Res. Toxicol. 15(3): 367-372, 2002.
- Pohanish, R.P. (editor): Crotonaldehyde. In, Sittig's Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 1. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 677-679.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Two Coated Glass Fiber Filters (Open Face) in one cassette separated by a spacer. The filters are coated with 2,4-Dinitrophenylhydrazine (DNPH) and Phosphoric Acid.
analytical solvent: Acetonitrile
maximum volume: 6 Liters maximum flow rate: 0.1 L/min
current analytical method: High Performance Liquid Chromatography; HPLC/UV
method reference: OSHA Analytical Method (OSHA 81)
method classification: Fully Validated
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Page last updated: 01/31/2006
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