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<title>Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies

U.S. Genome Variation Estimates

MTRR Allele and Genotype Frequencies
 Available polymorphism(s)
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rs number

Common Designations

Nucleotide change                                        Amino acid change

Genotyping method

rs1801394

Ex2-64A>G

Ile22Met
Ile49Met

TaqMan

 


 Allele and Genotype Frequencies for Subpopulations

 

BY RACE/ETHNICITY    [top]

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs1801394 A G   AA AG GG    
  Non-Hispanic White 47.2 (45.9, 48.5) 52.8 (51.5, 54.1) <0.001 22.6 (20.9, 24.4) 49.1 (47.1, 51.1) 28.3 (26.7, 29.9) <0.001 0.74
  Non-Hispanic Black 71.3 (69.1, 73.3) 28.7 (26.7, 30.9) 50.7 (47.8, 53.6) 41.1 (39.2, 43.1) 8.2 (6.8, 9.8) 0.82
  Mexican American 73.9 (72.0, 75.8) 26.1 (24.2, 28.0) 55.0 (51.8, 58.1) 37.9 (34.7, 41.3) 7.1 (5.7, 8.9) 0.04
  Total* 53.1 (51.5, 54.7) 46.9 (45.3, 48.5)   29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 

BY AGE*  [top]

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1801394 A G   AA AG GG  
  12-19 57.3 (51.0, 63.3) 42.7 (36.7, 49.0) 0.015 34.2 (27.9, 41.2) 46.1 (41.6, 50.6) 19.7 (14.0, 27.0) 0.060
  20-39 53.8 (51.4, 56.2) 46.2 (43.8, 48.6) 29.5 (26.0, 33.2) 48.6 (45.0, 52.2) 21.9 (19.7, 24.3)
  40-59 53.9 (50.7, 57.2) 46.1 (42.8, 49.3) 32.1 (27.5, 37.1) 43.7 (38.2, 49.3) 24.2 (20.7, 28.1)
  >=60 47.8 (45.2, 50.3) 52.2 (49.7, 54.8) 23.9 (20.8, 27.4) 47.7 (44.4, 50.9) 28.4 (25.7, 31.2)
  Total 53.1 (51.5, 54.7) 46.9 (45.3, 48.5)   29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)  

* Includes all participants, regardless of race/ethnicity.

 

BY SEX*  [top]

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs1801394 A G   AA AG GG  
  Male 53.5 (50.7, 56.3) 46.5 (43.7, 49.3) 0.604 29.3 (26.3, 32.6) 48.4 (45.5, 51.2) 22.3 (19.3, 25.5) 0.335
  Female 52.8 (51.4, 54.2) 47.2 (45.8, 48.6) 30.2 (28.2, 32.4) 45.2 (42.3, 48.0) 24.6 (22.8, 26.6)
  Total 53.1 (51.5, 54.7) 46.9 (45.3, 48.5)   29.8 (27.7, 31.9) 46.7 (45.0, 48.5) 23.5 (22.0, 25.0)  

* Includes all participants, regardless of race/ethnicity.

 

BY RACE/ETHNICITY AND AGE    [top]

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs1801394 A G AA AG GG
  Non-Hispanic White 12-19 49.7 (42.6, 56.8) 50.3 (43.2, 57.4) 25.4 (18.5, 33.8) 48.6 (42.1, 55.1) 26.0 (18.8, 34.8)
  20-39 46.5 (43.6, 49.5) 53.5 (50.5, 56.4) 20.1 (15.9, 25.0) 52.9 (47.8, 57.9) 27.0 (24.0, 30.3)
  40-59 49.8 (45.9, 53.7) 50.2 (46.3, 54.1) 27.2 (21.7, 33.6) 45.1 (38.7, 51.7) 27.6 (23.8, 31.9)
  >=60 43.5 (40.9, 46.0) 56.5 (54.0, 59.1) 19.4 (16.4, 22.7) 48.2 (44.6, 51.9) 32.4 (29.4, 35.6)
  Non-Hispanic Black 12-19 70.1 (66.5, 73.5) 29.9 (26.5, 33.5) 50.9 (46.2, 55.5) 38.5 (34.7, 42.4) 10.6 (7.8, 14.4)
  20-39 69.6 (66.5, 72.5) 30.4 (27.5, 33.5) 47.2 (42.8, 51.8) 44.7 (40.8, 48.6) 8.1 (6.1, 10.7)
  40-59 74.0 (69.5, 78.0) 26.0 (22.0, 30.5) 56.1 (49.7, 62.3) 35.8 (30.9, 41.0) 8.2 (5.5, 11.9)
  >=60 73.1 (70.1, 76.0) 26.9 (24.0, 29.9) 51.5 (47.6, 55.3) 43.3 (39.5, 47.3) 5.2 (2.8, 9.4)
  Mexican American 12-19 73.8 (68.5, 78.5) 26.2 (21.5, 31.5) 54.2 (46.5, 61.7) 39.2 (32.5, 46.4) 6.6 (3.5, 12.1)
  20-39 74.6 (72.1, 76.9) 25.4 (23.1, 27.9) 55.8 (50.9, 60.6) 37.6 (32.2, 43.3) 6.6 (5.0, 8.8)
  40-59 72.8 (69.8, 75.6) 27.2 (24.4, 30.2) 54.6 (50.9, 58.4) 36.4 (32.8, 40.1) 9.0 (6.3, 12.6)
  >=60 73.1 (69.7, 76.3) 26.9 (23.7, 30.3) 52.8 (48.1, 57.4) 40.7 (36.1, 45.6) 6.5 (3.8, 10.9)

 

 

BY RACE/ETHNICITY AND SEX    [top]

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs1801394 A G AA AG GG
  Non-Hispanic White Male 48.0 (45.7, 50.3) 52.0 (49.7, 54.3) 22.3 (19.9, 24.9) 51.4 (47.9, 54.9) 26.3 (23.3, 29.6)
  Female 46.4 (44.6, 48.3) 53.6 (51.7, 55.4) 23.0 (21.0, 25.1) 46.9 (43.4, 50.5) 30.1 (27.2, 33.1)
  Non-Hispanic Black Male 71.0 (68.0, 73.9) 29.0 (26.1, 32.0) 50.3 (45.8, 54.9) 41.4 (37.8, 45.1) 8.3 (6.5, 10.4)
  Female 71.5 (69.2, 73.6) 28.5 (26.4, 30.8) 51.0 (48.0, 54.0) 40.9 (38.5, 43.4) 8.1 (6.4, 10.1)
  Mexican American Male 74.3 (71.0, 77.4) 25.7 (22.6, 29.0) 55.5 (49.6, 61.3) 37.6 (32.0, 43.5) 6.9 (5.4, 8.8)
  Female 73.5 (71.4, 75.5) 26.5 (24.5, 28.6) 54.4 (51.7, 57.1) 38.2 (36.0, 40.5) 7.4 (5.7, 9.5)
Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics