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<title>Genomics|Population Research|U.S. Genome Variation Estimates|Frequencies

U.S. Genome Variation Estimates

ITGB3 Allele and Genotype Frequencies
 Available polymorphism(s)
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rs number

Common Designations

Nucleotide change          Amino acid change

Genotyping method

rs5918

Ex3+11T>C

Leu59Pro

MGB Eclipse

 


 Allele and Genotype Frequencies for Subpopulations

 

BY RACE/ETHNICITY    [top]

Variant Race-ethnicity Allele
% (95% CI)		 Chi-square
P-value†		 Genotype
% (95% CI)		 Chi-square
P-value†		 HW
P-value‡
rs5918 C T   CC CT TT    
  Non-Hispanic White 16.3 (15.0, 17.6) 83.7 (82.4, 85.0) <0.001 2.7 (1.8, 4.0) 27.2 (25.1, 29.4) 70.1 (67.9, 72.2) <0.001 0.81
  Non-Hispanic Black 10.1 (9.2, 11.0) 89.9 (89.0, 90.8) 1.1 (0.7, 1.7) 18.0 (16.3, 19.8) 81.0 (79.2, 82.6) 0.59
  Mexican American 9.7 (8.2, 11.3) 90.3 (88.7, 91.8) 1.3 (0.8, 2.1) 16.8 (14.8, 19.0) 81.9 (79.2, 84.4) 0.22
  Total* 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)    

* Includes all U.S. race/ethnic groups.
† “other" race/ethnicity category was not included in chi-square tests.
‡ P-values from unweighted chi-square goodness-of-fit tests to test for deviations from Hardy-Weinberg (HW) proportions.

 

BY AGE*  [top]

Variant Age (years) Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs5918 C T   CC CT TT  
  12-19 12.6 (10.2, 15.4) 87.4 (84.6, 89.8) 0.306 1.7 (0.7, 4.4) 21.7 (18.3, 25.7) 76.5 (72.1, 80.4) 0.629
  20-39 14.4 (12.7, 16.4) 85.6 (83.6, 87.3) 2.4 (1.3, 4.4) 24.0 (21.5, 26.7) 73.6 (70.7, 76.3)
  40-59 15.3 (13.4, 17.3) 84.7 (82.7, 86.6) 2.2 (1.2, 3.9) 26.2 (22.5, 30.4) 71.6 (67.8, 75.2)
  >=60 14.5 (13.3, 15.9) 85.5 (84.1, 86.7) 2.3 (1.7, 3.1) 24.5 (22.4, 26.7) 73.2 (70.9, 75.5)
  Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)  

* Includes all participants, regardless of race/ethnicity.

 

BY SEX*  [top]

Variant Sex Allele
% (95% CI)		 Chi-square
P-value		 Genotype
% (95% CI)		 Chi-square
P-value
rs5918 C T   CC CT TT  
  Male 14.3 (12.6, 16.1) 85.7 (83.9, 87.4) 0.762 2.7 (1.8, 4.1) 23.1 (20.3, 26.2) 74.2 (71.0, 77.1) 0.069
  Female 14.6 (13.3, 16.0) 85.4 (84.0, 86.7) 1.8 (1.1, 2.9) 25.6 (23.7, 27.5) 72.6 (70.4, 74.8)
  Total 14.4 (13.3, 15.6) 85.6 (84.4, 86.7)   2.2 (1.5, 3.3) 24.4 (22.7, 26.2) 73.4 (71.4, 75.2)  

* Includes all participants, regardless of race/ethnicity.

 

BY RACE/ETHNICITY AND AGE    [top]

Variant Race-ethnicity Age (years) Allele
% (95% CI)		 Genotype
% (95% CI)
rs5918 C T CC CT TT
  Non-Hispanic White 12-19 14.3 (11.1, 18.1) 85.7 (81.9, 88.9) 1.7 (0.5, 5.2) 25.1 (19.7, 31.6) 73.2 (66.6, 78.9)
  20-39 16.8 (14.7, 19.2) 83.2 (80.8, 85.3) 3.1 (1.6, 6.0) 27.4 (24.4, 30.6) 69.5 (66.1, 72.6)
  40-59 16.8 (14.7, 19.0) 83.2 (81.0, 85.3) 2.6 (1.3, 5.0) 28.4 (24.5, 32.8) 69.0 (65.0, 72.7)
  >=60 15.8 (14.3, 17.4) 84.2 (82.6, 85.7) 2.6 (1.8, 3.7) 26.4 (24.2, 28.7) 71.0 (68.4, 73.5)
  Non-Hispanic Black 12-19 9.2 (7.6, 11.1) 90.8 (88.9, 92.4) 1.0 (0.5, 1.7) 16.4 (13.6, 19.7) 82.6 (79.1, 85.6)
  20-39 10.1 (8.7, 11.8) 89.9 (88.2, 91.3) 0.9 (0.4, 1.9) 18.4 (15.5, 21.9) 80.6 (77.4, 83.6)
  40-59 10.9 (9.1, 13.2) 89.1 (86.8, 90.9) 1.6 (0.7, 3.4) 18.7 (15.5, 22.4) 79.7 (75.9, 83.0)
  >=60 9.4 (6.8, 12.7) 90.6 (87.3, 93.2) 0.8 (0.2, 3.2) 17.2 (12.2, 23.7) 82.0 (75.6, 87.0)
  Mexican American 12-19 7.5 (4.9, 11.5) 92.5 (88.5, 95.1) 0.0 (NA) 15.1 (9.7, 22.7) 84.9 (77.3, 90.3)
  20-39 10.9 (9.3, 12.8) 89.1 (87.2, 90.7) 2.0 (1.1, 3.7) 17.8 (15.4, 20.5) 80.2 (77.2, 82.9)
  40-59 8.6 (6.9, 10.7) 91.4 (89.3, 93.1) 0.6 (0.2, 2.1) 16.1 (13.3, 19.2) 83.3 (79.8, 86.4)
  >=60 10.0 (6.5, 15.0) 90.0 (85.0, 93.5) 1.6 (0.2, 10.3) 16.8 (11.7, 23.7) 81.6 (74.1, 87.3)

 

 

BY RACE/ETHNICITY AND SEX    [top]

Variant Race-ethnicity Sex Allele
% (95% CI)		 Genotype
% (95% CI)
rs5918 C T CC CT TT
  Non-Hispanic White Male 16.3 (14.3, 18.5) 83.7 (81.5, 85.7) 3.2 (2.1, 4.9) 26.2 (22.7, 30.0) 70.6 (66.8, 74.1)
  Female 16.3 (14.7, 18.0) 83.7 (82.0, 85.3) 2.2 (1.3, 3.6) 28.2 (25.8, 30.7) 69.7 (66.9, 72.3)
  Non-Hispanic Black Male 9.6 (8.5, 10.8) 90.4 (89.2, 91.5) 1.0 (0.5, 2.0) 17.1 (15.2, 19.2) 81.9 (79.7, 83.8)
  Female 10.5 (9.4, 11.7) 89.5 (88.3, 90.6) 1.1 (0.6, 2.1) 18.7 (16.4, 21.2) 80.2 (77.9, 82.3)
  Mexican American Male 10.2 (8.7, 11.8) 89.8 (88.2, 91.3) 1.4 (0.7, 2.7) 17.5 (14.9, 20.5) 81.1 (78.1, 83.7)
  Female 9.1 (7.2, 11.5) 90.9 (88.5, 92.8) 1.1 (0.5, 2.4) 16.0 (12.8, 19.9) 82.9 (78.7, 86.3)
Page last reviewed: October 21, 2008 (archived document)
Page last updated: October 21, 2008
Content Source: National Office of Public Health Genomics