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Computational Toxicology Research

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ExpoCast™

Exposure characterization is the risk analysis step in which human interaction with an environmental agent of concern is evaluated. Exposure is defined as the contact between an agent and a target (WHO, 2004).

Exposure science is the bridge between the sources of chemical, physical, and biological agents and human health. It is used to estimate real-life risks to health and to identify the most effective ways to reduce these risks. EPA's Computational Toxicology Research advances characterization of the exposure required to translate findings in computational toxicology to support risk assessment through its ExpoCast research project.

ExpoCastâ„¢ Key Points
  • Works with EPA's ToxCast tool to help determine priority chemicals that may need further screening or to be regulated.
  • Develops novel approaches for evaluating chemicals based on potential for biologically relevant human exposure.
  • Collaborates with stakeholder groups to mine and apply scientific advances and tools in a broad range of fields.
  • Developing prioritization tools that will include public accessible and searchable exposure databases and an exposure screening tools for accelerated chemical prioritization.

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