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UPDATE: May 2009 | MW: 9.01 | MF: Be |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
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N/R
|
N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
|
ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
|
DNA adduct
|
Escherichia coli
|
30 µmol/L
|
MUREAV 89,95,1981
|
DNA adduct
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human
HeLa cell
|
30 µmol/L
|
MUREAV 89,95,1981
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DNA adduct
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mouse
Ascites tumor
|
30 µmol/L
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MUREAV 89,95,1981
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DNA inhibition
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intravenous | non-mammalian species
30 µmol/kg
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PHMCAA 12,298,1970
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
N/R |
N/R
|
N/R
|
N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
intratracheal | rat
lowest published toxic dose: 13 mg/kg
|
Tumorigenic: Neoplastic by RTECS criteria | Lung, Thorax, or Respiration: Tumors Lung, Thorax, or Respiration: Bronchogenic carcinoma
ENVRAL 21,63,1980
|
intravenous | rabbit
lowest published toxic dose: 20 mg/kg
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Tumorigenic: Equivocal tumorigenic agent by RTECS criteria | Musculoskeletal: Tumors
LANCAO 1,463,1950
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | rat
lowest published toxic concentration: 0.8 mg/m3/50 minute
|
Lung, Thorax, or Respiration: Fibrosis (interstitial) | Blood: Hemorrhage Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation
HBTME* -,415,2007
|
inhalation | rat
lowest published lethal concentration: 0.8 mg/m3/50 minute
|
N/R
|
HBTME* -,415,2007
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intratracheal | rat
lethal dose (50 percent kill): 51 mg/kg
|
N/R
|
STGNBT -,23,1999
|
intravenous | rat
lethal dose (50 percent kill): 496 µg/kg
|
Liver: Hepatitis (hepatocellular necrosis), zonal
|
LAINAW 15,176,1966
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
|
| EFFECT
REFERENCE
|
inhalation | human
lowest published toxic concentration: 2 µg/m3/8 hour/26 week- intermittent
|
Lung, Thorax, or Respiration: Cough | Lung, Thorax, or Respiration: Cyanosis Lung, Thorax, or Respiration: Other changes
FEREAC 67,70707,2002
|
inhalation | mammal (species unspecified)
lowest published toxic concentration: 20 ng/m3/1 hour/17 week- intermittent
|
Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases
STGNBT -,23,1999
|
inhalation | rat
lowest published toxic concentration: 20 ng/m3/8 hour/26 week- intermittent
|
Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) | Nutritional and Gross Metabolic: Weight loss or decreased weight gain Biochemical: Metabolism (intermediary): Other proteins
STGNBT -,23,1999
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oral | mouse
lowest published toxic dose: 4,000 µg/kg/20 week- intermittent
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Lung, Thorax, or Respiration: Other changes
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TOXID9 -,223,2008
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REVIEWS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
time-weighted average 0.002 mg/m3;short term exposure limit 0.01 mg/m3
|
DTLVS* TLV/BEI,2007
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
|
Confirmed human carcinogen
|
DTLVS* TLV/BEI,2007
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Sufficient Evidence
|
IMEMDT 1,17,1972
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Sufficient Evidence
|
IMEMDT 23,143,1980
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Animal Sufficient Evidence
|
IMEMDT 58,41,1993
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Limited Evidence
|
IMEMDT 23,143,1980
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Human Sufficient Evidence
|
IMEMDT 58,41,1993
|
International Agency for Research on Cancer (IARC) Cancer Review
|
Group 1
|
IMEMDT 58,41,1993
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TOXICOLOGY REVIEW
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CRTXB2 1,235,1972
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TOXICOLOGY REVIEW
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85CVA2 5,63,1970
|
TOXICOLOGY REVIEW
|
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CTOXAO 6,497,1973
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TOXICOLOGY REVIEW
|
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AEMBAP 40,239,1973
|
TOXICOLOGY REVIEW
|
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AJMEAZ 38,409,1965
|
TOXICOLOGY REVIEW
|
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NTIS** CONF-691001
|
TOXICOLOGY REVIEW
|
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AMTODM 3,209,1977
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TOXICOLOGY REVIEW
|
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SCIEAS 201,298,1978
|
TOXICOLOGY REVIEW
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TOLED5 127,63,2002
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TOXICOLOGY REVIEW
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TXAPA9 197,144,2004
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TOXICOLOGY REVIEW
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DIMON* 39,678,1993
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TOXICOLOGY REVIEW
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ENTOX* -,265,2005
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TOXICOLOGY REVIEW
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MUREAV 544,313,2003
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TOXICOLOGY REVIEW
|
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HTOPA* 1,701,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
|
STANDARD
|
| REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air
|
time-weighted average 0.002 mg/m3
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DTLVS* 3,24,1971
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)
|
8 hour time-weighted average 0.002 mg(Be)/m3
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CFRGBR 29,1910.1000,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)
|
8 hour time-weighted average 0.002 mg(Be)/m3
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CFRGBR 29,1926.55,1994
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)
|
8 hour time-weighted average 0.002 mg(Be)/m3
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CFRGBR 29,1915.1000,1993
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Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)
|
8 hour time-weighted average 0.002 mg(Be)/m3
|
CFRGBR 41,50-204.50,1994
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Occupational Exposure Limit - ARAB Republic of Egypt
|
time-weighted average 0.002 mg/m3, JAN1993
|
Occupational Exposure Limit - AUSTRALIA
|
time-weighted average 0.002 mg/m3, Carcinogen, JUL2008
|
Occupational Exposure Limit - AUSTRIA
|
TRK 0.002 mg(Be)/m3 (inhalable), JAN 2006
|
Occupational Exposure Limit - AUSTRIA
|
TRK 0.005 mg/m3 (inhalable), JAN 2006
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Occupational Exposure Limit - BELGIUM
|
time-weighted average 0.002 mg/m3, Carcinogen, MAR2002
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Occupational Exposure Limit - DENMARK
|
time-weighted average 0.001 mg(Be)/m3, OCT 2002
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Occupational Exposure Limit - DENMARK
|
time-weighted average 0.001 mg/m3, OCT 2002
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Occupational Exposure Limit - FINLAND
|
time-weighted average 0.002 mg/m3, short term exposure limit 0.006 mg/m3, Carcinogen, JAN1999
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Occupational Exposure Limit - HUNGARY
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ceiling concentration 0.002 mg/m3, Carcinogen, SEP2000
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Occupational Exposure Limit - INDIA
|
time-weighted average 0.002 mg/m3, Carcinogen, JAN1993
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Occupational Exposure Limit - JAPAN
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Occupational Exposure Limit 0.002 mg/m3, 2A carcinogen, sen, APR2007
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Occupational Exposure Limit - KOREA
|
time-weighted average 0.002 mg/m3, 2006
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Occupational Exposure Limit - MEXICO
|
time-weighted average 0.002 mg/m3, 2004
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Occupational Exposure Limit - NEW ZEALAND
|
time-weighted average 0.002 mg/m3, carcinogen, JAN2002
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Occupational Exposure Limit - NORWAY
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time-weighted average 0.001 mg/m3, JAN1999
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Occupational Exposure Limit - THE PHILIPPINES
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time-weighted average 0.002 mg/m3, JAN1993
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Occupational Exposure Limit - POLAND
|
MAC(time-weighted average) 0.001 mg/m3, MAC(short term exposure limit) 0.003 mg/m3, JAN1999
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Occupational Exposure Limit - RUSSIA
|
time-weighted average 0.001 mg/m3, short term exposure limit 0.003 mg/m3, Carcinogen, JUN2003
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Occupational Exposure Limit - SWEDEN
|
time-weighted average 0.002 mg/m3, Carcinogen, Sen, JUN2005
|
Occupational Exposure Limit - SWITZERLAND
|
MAK- week 0.002 mg/m3, Carcinogen, DEC2006
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Occupational Exposure Limit - THAILAND
|
time-weighted average 0.002 mg/m3, short term exposure limit 0.005 mg/m3, JAN1993
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Occupational Exposure Limit - TURKEY
|
time-weighted average 0.002 mg/m3, JAN1993
|
Occupational Exposure Limit - UNITED KINGDOM
|
time-weighted average 0.002 mg/m3, 2005
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Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; | Confirmed human carcinogen
Occupational Exposure Limit IN SINGAPORE, VIETNAM
|
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value |
Confirmed human carcinogen |
NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
|
STANDARD or SURVEY
|
| REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BERYLLIUM-air
|
Carcinogen not to exceed 0.0005 mg(Be)/m3
|
NIOSH* DHHS #92-100,1992
|
National Occupational Hazard Survey 1974
|
National Occupational Hazard Survey 1974: Hazard Code: 11770; | Number of Industries 8; Total Number of Facilities 344; Number of Occupations 17; Total Number of Employees Exposed 10,510
National Occupational Exposure Survey 1983
|
National Occupational Exposure Survey 1983: Hazard Code: 11770 |
![]() Number of Industries 22; Total Number of Facilities 421; Number of Occupations 29; Total Number of Employees Exposed 13,938; Total Number of Female Employees Exposed 739 |
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
|
| REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/93/182392/AS)
|
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
|
EPA TSCA Section 8(b) CHEMICAL INVENTORY
|
Used in manufacturing for electrical components, nuclear reactors and in aerospace industry
|
EPA TSCA Section 8(d) unpublished health/safety studies
|
On EPA IRIS database
|
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
|
NIOSH Analytical Method, 1994: Beryllium and compounds, as Be, 7102
|
NIOSH Analytical Method, 1994: Elements by ICP, 7300
|
NTP 11th Report on Carcinogens,2004:Known to be human carcinogen
|
OSHA ANALYTICAL METHOD #ID125G
|
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REFERENCES:
CODEN
|
| REFERENCE
85CVA2
|
"Oncology 1970, Proceedings of the Tenth International Cancer Congress," Chicago, Year Book
Medical Pub., 1971
|
AEMBAP
|
Advances in Experimental Medicine and Biology. (Plenum Pub. Corp., 233 Spring St., New York,
NY 10013) V.1- 1967-
|
AJMEAZ
|
American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1-
1946-
|
AMTODM
|
Advances in Modern Toxicology. (John Wiley & Sons, Inc., 605 Third Ave., New York, NY 10016)
V.1, 1976-79. Discontinued.
|
CFRGBR
|
Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents,
Washington, DC 20402)
|
CRTXB2
|
CRC Critical Reviews in Toxicology. (CRC Press, Inc., 2000 Corporate Blvd., NW, Boca Raton,
FL 33431) V.1- 1971-
|
CTOXAO
|
Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
|
DIMON*
|
Disease-a Month (Chicago : Year Book Publishers) V. 24- 1978-
|
DTLVS*
|
The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by
American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
|
ENTOX*
|
Encyclopedia of Toxicology: Reference Book, Elsevier, 2005
|
ENVRAL
|
Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-
1967-
|
FEREAC
|
Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
|
HBTME*
|
|
HTOPA*
|
|
IMEMDT
|
IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications
Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
|
LAINAW
|
Laboratory Investigation. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202)
V.1- 1952-
|
LANCAO
|
Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823-
|
MUREAV
|
Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
|
NIOSH*
|
National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and
Welfare, Reports and Memoranda.
|
NTIS**
|
National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
|
PHMCAA
|
Pharmacologist. (American Soc. for Pharmacology and Experimental Therapeutics, 9650 Rockville
Pike, Bethesda, MD 20014) V.1- 1959-
|
SCIEAS
|
Science. (American Assoc. for the Advancement of Science, 1333 H St., NW, Washington, DC
20005) V.1- 1895-
|
STGNBT
|
"Spravochnik po Toksikologii i Gigienicheskim Normativam (PDK) Potentsial'no Opasnykh
Khimicheskikh Veshchestv" Kushneva, V.S., and R.B. Gorshkova, eds. 46, Zhivopisnaya St.,
123182, Moscow, Russia, IzdAT 1999
|
TOLED5
|
Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
|
TOXID9
|
Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1-
1981-
|
TXAPA9
|
Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802)
V.1- 1959-
|
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