Treatment Recommendations: Medications (Continued)
Meta-analysis (2008): Effectiveness and abstinence rates for various medications and medication combinations compared to placebo at 6-months post-quit (n = 86 studies)
| Medication |
Number of arms |
Estimated odds ratio (95% C.I.) |
Estimated abstinence rate (95% C.I.) |
| Placebo |
80 |
1.0 |
13.8 |
| Monotherapies |
|
|
|
| Varenicline (2 mg/day) |
5 |
3.1 (2.5, 3.8) |
33.2 (28.9, 37.8) |
| Nicotine Nasal Spray |
4 |
2.3 (1.7, 3.0) |
26.7 (21.5, 32.7) |
| High Dose Nicotine Patch (> 25 mg) (These included both standard or long-term duration) |
4 |
2.3 (1.7, 3.0) |
26.5 (21.3, 32.5) |
| Long-Term Nicotine Gum (> 14 weeks) |
6 |
2.2 (1.5, 3.2) |
26.1 (19.7, 33.6) |
| Varenicline (1 mg/day) |
3 |
2.1 (1.5, 3.0) |
25.4 (19.6, 32.2) |
| Nicotine Inhaler |
6 |
2.1 (1.5, 2.9) |
24.8 (19.1, 31.6) |
| Clonidine |
3 |
2.1 (1.2, 3.7) |
25.0 (15.7, 37.3) |
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