Basic Trial Information
Trial Description
Summary
Further Trial Information
Eligibility Criteria
Trial Contact Information
Phase | Type | Status | Age | Sponsor | Protocol IDs |
---|---|---|---|---|---|
Phase IV | Health services research, Treatment | Active | 18 and over | Other | Plerixafor-UF01 NCT01339572 |
Summary
This protocol will investigate the effectiveness of plerixafor in the up-front setting in avoiding a second round of mobilization and whether this translates into a clinical and economic benefit.
Further Study Information
Peripheral blood stem cells are now considered the standard source of stem cells for autologous stem cell transplants. Unfortunately, there is still a 20-30% chance that inadequate numbers of stem cells will be collected, resulting in prolonged recovery of cell counts after transplantation and increased transfusion dependence. There is also a significant economic burden associated with remobilization and a risk that delays in collecting sufficient numbers of stem cells can result in an increased chance of disease recurrence prior to transplantation.
Eligibility Criteria
Inclusion Criteria:
- Patients with multiple myeloma or non-Hodgkin's lymphoma with a planned autologous transplant and who are eligible for peripheral stem cell mobilization.
- Karnofsky Performance Status ≥ 70.
- Age ≥ 18
- Less than 30% involvement of marrow with disease.
Exclusion Criteria:
- > 30% marrow involvement with disease
- Age < 18.
- Pregnant women.
Trial Lead Organizations/Sponsors
University of Florida Shands Cancer Center
Jack W Hsu, MD | ![]() | Principal Investigator |
Christine NeJame, RN | ![]() | Ph: 352-273-6838 |
Email: cnejame@ufl.edu |
Trial Sites
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U.S.A. | |||
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Florida | |||
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Gainesville | |||
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University of Florida Shands Cancer Center | |||
Christine NeJame, RN | Ph: 352-273-6838 | ||
Jack W Hsu, MD | Principal Investigator | ||
Link to the current ClinicalTrials.gov record.
NLM Identifer NCT01339572
Information obtained from ClinicalTrials.gov on September 25, 2012
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