Dark Matter of Genomic Associations With Complex Diseases:
Explaining the Unexplained Heritability From Genome-Wide Association Studies
Background Materials
- Gibson G. Decanalization and the origin of complex disease. Nat Rev Genet, (2):134-40. 2009. [PubMed]
- Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet, (6):695-701. Review. 2008. [PubMed]
- Donnelly P. Progress and challenges in genome-wide association studies in humans. Nature, 456(7223):728-31. 2008. [PubMed]
- Kong A, Masson G, Frigge ML, et al. Detection of sharing by descent, long-range phasing and haplotype imputation. Nat Genet, 40(9):1068-75. 2008. [PubMed]
- Maher B. Personal genomes: The case of the missing heritability. Nature, 6;456(7218):18-21. 2008. [PubMed]
- Mardis ER. The impact of next-generation sequencing technology on genetics. Trends Genet, (3):133-41. 2008. [PubMed]
- McCarroll SA. Extending genome-wide association studies to copy-number variation. Hum Mol Genet, 17(R2):R135-42. Review. 2008. [PubMed]
- Visscher PM, Hill WG, Wray NR. Heritability in the genomics era--concepts and misconceptions. Nat Rev Genet, (4):255-66. Review. 2008. [PubMed]
- Weiss KM. Tilting at quixotic trait loci (QTL): an evolutionary perspective on genetic causation. Genetics, (4):1741-56. Review. 2008. [PubMed]
- Feinberg AP. Phenotypic plasticity and the epigenetics of human disease. Nature, 447(7143):433-40. 2007. [PubMed]
- Brem RB, Kruglyak L. The landscape of genetic complexity across 5,700 gene expression traits in yeast. Proc Natl Acad Sci U S A, 102(5):1572-7. 2005. [PubMed]
Last Reviewed: November 4, 2010