Highlights
Biological Sciences Division
2012
Research Highlights
- Lung Imaging Research Gets Its Second Wind
Bytes versus breathsSeptember - Mass Spec Makes the Clinical Grade
Protein assays matching sensitivity and accuracy of antibody-based clinical tests might speed drug discovery, basic biology researchSeptember - New Protein Discovered Gives Insights to Iron's Fate Underground
Scientists identify molecule that steals electrons, leaving iron stuck in the mudAugust - Turning Down the Heat for Carbon
Unusual reaction eschews high temperatures and water to lock away climate-changing carbon dioxideAugust - Unique Protein Fold Flags Potentially Unique Function
Crystal structure of a cyanobacterial protein associated with nitrogen fixationJuly - Teaming, Integration Lead to R&D 100 Award
Graphene nanostructures for lithium batteries enable rapid recharge of electric vehicles and consumer electronic productsJune - Collaborative Study Looks for Clues on Hard-to-Treat Breast Cancer
PNNL, Walter Reed, and Windber to scour triple negative breast cancer for leads on diagnostics and drugsJune - Annotating Plague with Proteogenomics
Multifaceted strategies help refine annotations of three Yersinia strainsMay - Human Skin Model Shows Signaling Pathway Effects from Low Dose Exposure
Model gives good representation of intact tissueApril - Proteomics Identifies Targets of Ionizing Radiation in a Human Skin Model
Found unique phosphopeptides showing changes in response to doseApril - Study Dusts Sugar Coating Off Little-Known Regulation In Cells
O-GlcNAc regulatory system adds complexity in cell regulation, could eventually provide new drug targetsApril - Genome-Scale Model of Cyanobacterium Developed
Cyanothece's complete metabolism describedApril - Same Samples, Different Analytical Strategies, Complementary Inferences
Two approaches to further understanding of subsurface microbial communities published togetherApril - Tasting Carbon with WAFT'ed Light
New instrument analyzes tiny samples at low pressure and temperatureApril - Shedding Light on Photosynthesis
Dynamic proteome analysis of Cyanothece 51142April - Pinpointing Plutonium Proclivities
New study queries interactions of metal-reducing bacteria with plutonium oxideMarch - Digging Deeper in the Dirt
Targeted metagenomic analyses reveal underground microbes that may influence and alter contaminant fate and transport at Hanford SiteMarch - Taking Stock of Subsurface Microbial Communities at Hanford
Census improves understanding of how microbes influence contaminant behaviorMarch - Bacteria Tend Leafcutter Ants' Gardens
Microbes turn leaves into nutrients; knowledge could improve biofuel productionMarch - Small-Scale Soil Studies Provide Big Benefits
Aggregate assays show more about microbial communitiesFebruary - Modeling Microbes to Manage Carbon Dioxide
Model developed to understand microbial processes in cellulose degradationFebruary - Studying the Chemistry as It Happens in Catalytic Reactions
New probe shows the in-between stages of a reaction under realistic conditionsJanuary
2012
Staff Awards and Honors
- PNNL Scientist Receives Early Career Research Award
May - Modeling Paper Wins Society of Toxicology Award
Model links exposure and dose from pesticideMarch - Kodali, Sharma Named Outstanding Postdocs for Nanotox Research
March - Keqi Tang and Ryan Kelly Win Technology Transfer Award
February
2011
Research Highlights
- Lipidomics Leads to Paper's Selection as Editor's Choice
Authors identify lipid profile characteristic of newly diagnosed type 1 diabetesDecember - Fluorescent Probes Increase Understanding of Bacterium's Electron Transfer
Electron migration via protein trafficking tightly regulated by cellDecember - PNNL Chosen as a Premier Proteomics Center for Cancer
Lab resources will benefit the Clinical Proteomic Tumor Analysis ConsortiumOctober - Addressing How Cigarettes Cause Cardiovascular Disease
Antibody microarray analysis provides insight about mechanisms of lung diseaseOctober - 2011 Fundamental & Computational Sciences Accomplishments Report Now Available
October - Investigating Infectious Disease Interactions
Multi-omics strategy gives systems-level insight toward Salmonella pathogenesisSeptember - New Thermodynamic Model Predicts Plutonium Solubility with Iron
Research could benefit subsurface studies worldwideAugust - Clustering Is Key to Lighting Up the Dark Proteome
Spectral archives let researchers leverage unidentified spectraAugust - A "Hair-Lasing" Tale
Ultraviolet laser measures carbon isotopes for accurate evaluationJuly - Array Detection Technology Wins R&D 100 Award
July - Addressing High False-Positive Rates for Mammograms
Antibody microarray analysis holds promise for increasing accuracy of breast cancer screeningJune - A Four-Dimensional View of Breast Cancer Treatment
OHSU researcher describes spatial systems approach to better understand diseaseJune - Metabolic Models Make Remediation More Manageable
University of Toronto scientist describes research to model uranium reduction in subsurfaceJune - New Research Details Structure of First Component in an Electricity-conducting Bacterial Wire
Architectural insights of proteins that make up the wires might help researchers immobilize metal contaminants or engineer bio-inspired fuel cellsJune - Wetter is Better
New microscopy methods improve accuracy of microbial biofilm imagingApril - Defending Against Disease
Predicting immune system responses to various stimuliApril - Top-to-Bottom Protein Characterization
Pressurized pepsin digestion as an automatable alternative to trypsinApril - Unique Spinal Fluid Proteins Found in Chronic Fatigue, Lyme Disease Syndrome Patients
Results suggest both CFS and neurologic post-treatment Lyme disease syndrome involve central nervous system but are different illnessesMarch - Microbially Produced Ferrous Iron May Decrease Technetium Concentrations in Groundwater
Competition between microbial and geochemical reactions plays key role in influencing soluble technetium concentrationsFebruary - Modeling Radiation Energy Deposition in a Complex Biological System
Using a skin tissue model for the study of low-dose radiation-induced tissue responsesFebruary - Taking the Mystery Out of Photosynthesis
Theory, experiments uncover structure of oxygen-evolving complexFebruary - Mass Spec Tool Makes Search for Martian Life Easier
February - Even Algae Get Stressed
A typical stress response for algae influences photosynthetic productivityJanuary - Sequenced Genomes Make Good Neighbors
Comparing mass spectra among organisms enables protein identificationJanuary
2011
Staff Awards and Honors
- Joel Pounds Leads Review Panel for Lead Health Effects Report
Panel concurs with report stating that low lead levels impact healthDecember - Vanessa Bailey Appointed to Soil Science Journal Editorial Board
December - Karin Rodland Elected AAAS Fellow
December - Herman Cho, Scott Chambers, and Dick Smith Continue as Wiley Research Fellows
October - Josh Adkins to Participate in Keck Futures Initiative Conference
October - Tony Brooks Chosen As Lauriston S. Taylor Lecturer
October - Wei-Jun Qian Wins Government's Highest Science and Engineering Award
October - Fredrickson Elected to Washington State Academy of Sciences
July - PNNL Protein Structure Research Featured in Special Issue
July - Joel Pounds Joins Ranks of Laboratory Fellows
July - Bill Morgan Named Laboratory Fellow
July - Keqi Tang Receives Outstanding Mentor Award
Former PNNL staff member Anuj Shah also recognizedMay - Bill Morgan Elected to Main Commission of International Commission on Radiation Protection
May - PNNL Scientist Wins Early Career Program Award
May - EMSL Selects First-Ever Research Campaigns
Teams aim for groundbreaking results in catalysis, biomass processesMarch - Health Physics Special Issue Features Contributions by Bill Morgan, Tony Brooks
February - PNNL Scientists Most Prolific Authors in Proteomic Journal
February - Spinal Fluid Research Wins Gordon Battelle Prize
January - Bill Morgan Named AAAS Fellow
January - Allan Konopka Named AAAS Fellow
January
2010
Research Highlights
- Just How Fast Can Bacteria Grow? It Depends.
Proteomics Data Validate Model of Bacterial GrowthDecember - Proteomic Profiling of Low-Dose Radiation Effects on Human Skin Cells
Unique radiation-responsive proteins affected by low doses of ionizing radiationDecember - Seeing Diffusion from the Atom's Perspective
A new approach to calculating uranium diffusion challenges traditional equationsDecember - Check Out the Fundamental & Computational Sciences Achievements for 2010
December - Understanding Protein Structure and Function is Goal of New NIH Project
Information can help treat disease, infectionsNovember - Mediation on the Molecular Level
Molecular interactions hold key to how nanoparticles behave in cellsNovember - Identifying the Degradome
Protein pieces provide path toward early detection of breast cancerNovember - Monkeypox Study Reveals Clues to Virus's Role in Lung Disease
Findings might help better understand bronchitis, emphysema, other lung diseaseNovember - Award-Winning Ion Funnel Technology Gets Another License
Agilent introduces newest commercial version: iFunnelOctober - Long-Distance Communication, Microbial Style
Scientists demonstrate how microbes communicate without touchingOctober - New Tool Developed to Better Isolate Neutrophils
Better understanding and diagnoses of immune system injurySeptember - Getting to the Root of Climate Change
PNNL scientists to probe proteomics of soybean root hairsSeptember - Looking for Secrets to Drug Addiction in Our Blood
September - From Predictions to Reality: Genomics Reveals Microbe's Metabolic Potential
Systems-level understanding of Shewanella metabolism directed toward biofuel productionSeptember - It Takes "Guts" to Explore the Next Proteomics Frontier
Looking at bacterial communities in termite gut helps reconstruct metabolic pathwaysJuly - Thousands of New Proteins Discovered in Spinal Fluid
Research establishes healthy benchmark to aid in understanding neurological disordersJuly - New Analytical Platform is Making the Nearly Impossible Routine
Analytical 2 + 2 = 5!June - Novel Indicators of Oxidative Stress in Disease
Proteomics study offers clues to how diseases such as Parkinson's progressJune - Small Particles, Big Impact
Distinguished professor discusses nanoparticles and the environment at PNNL seminarJune - Silica Cages Help Anti-Cancer Antibodies Kill Tumors in Mice
Honeycombed particles filled with cancer drug act like time-release capsules at tumor siteMay - Graphene-DNA Biosensor Selective, Simple to Create
Nanostructure could help diagnose disease, facilitate gene therapy, moreMay - Strategy to Quantify, Purify Surface Proteins Also Shows Effects on Protein Translocation
Proteins expressed by Shewanella have novel roles in cell substratesMay - Modeling Microbes and Minerals
Expert profiles microbe activity in acid mine drainageApril - More Proof of Outer Membrane Cytochrome Role in Electron Transfer
Shewanella cytochromes reduce and transform the widespread mineral ferrihydriteApril - Understanding the Potential of a Single Crystal
Award-winning Croatian professor speaks at PNNL's geochemistry seminarApril - When the Air Turns Brown
Scientists discover reactions that create climate-changing brown carbon aerosolApril - First NMR Signal of a Copper Site in Azurin Obtained
High-field, low-temperature NMR harvests unprecedented characterization of metalloproteinsFebruary - Taking Infectious Disease in STRIDE
PNNL part of new systems biology center led by UWFebruary - Bacteria Are Better Gene Packers Than We Thought
Proteomics improve gene annotation and detectionJanuary - Are Radiation-Induced Bystander Effects a Universal Phenomenon?
Studies on human cells fail to find low-LET radiation-induced damage in untargeted cells.January
2010
Staff Awards and Honors
- Bill Morgan and Marianne Sowa Honored by Mutation Research
December - Jordan Smith to Receive Best Postdoc Publication Award
December - Dick Smith Named Scientist of the Year
November - Jim Fredrickson and Allan Konopka Join Editorial Board of ISME Journal
October - Dave Koppenaal Appointed to Editorial Board of Metallomics
October - Dick Smith Elected to Second Term on HUPO Board
October - Dick Smith up for R&D Magazine's Scientist of the Year
September - Jim Fredrickson Elected to International Microbial Ecology Board
September - Koppenaal Co-Editor-in-Chief of New Edition of Spectrometry/Spectroscopy Encyclopedia
Several PNNL staff contributedSeptember - Konopka, Smith Elected to Washington State Academy of Sciences
September - John Zachara Named Battelle Fellow
September - PNNL Scientists Win R&D 100 Awards for Biology, Environment Technologies
Ion Mobility Spectrometer on a Microchip and IncubATR™—the Live-Cell MonitorJuly - Wei-Jun Qian Receives DOE Early Career Award
June - Dick Smith Named One of Innovation magazine's "Best and the Brightest"
May - Talented Mentors Recognized for Contributions to Teacher, Students
May - Jim Morris, Kathy Ertell Appointed to National DOE Human Research Board
May - Bill Morgan Elected to NCRP Board of Directors
April - Marianne Sowa Serves as Guest Editor for Special Issue of Mutation Research
April - Karin Rodland Named U.S. HUPO Board Member
March - PNNL Postdoc Wins DOD Breast Cancer Fellowship Award
February - Dani López-Ferrer Wins Tech Transfer Award
High-pressure enzymatic digestion system licensed to Pressure BioSciences, Inc.January - Richard Smith Selected for Analytical Chemistry Award
January
2009
Research Highlights
- Scientists Show How Bacteria Move Electrons Across a Membrane
First demonstration of protein complex that catalyzes electron transfer to the cell exteriorDecember - Protein That Controls Cell Growth Gives Good Oscillations
Findings featured in Molecular Systems BiologyDecember - Unique Uranium Source in Naturally Bioreduced Sediment
First time uranium associated with framboidal pyrite at contaminated siteNovember - Building Better Biofuels
Expert describes research at DOE Great Lakes Bioenergy Research CenterNovember - Where Did the Uranium Go?
Experiments, model help scientists describe uranium's path under different conditionsOctober - Building Up Broken Bones
New funding will help PNNL scientists develop material to promote bone regenerationOctober - New Below-Ground Monitoring Method for Microbial Activity Validated at Colorado Site
Geophysical monitoring approach provides "x-ray" images of subsurface biogeochemical processesOctober - Check Out the Fundamental & Computational Sciences Achievements for 2009
September - Check Out Advancing the Frontiers of Science Brochure
September - Making Needles in the Haystack Easier to Find
Online protein separation strategy helps detect low-abundance proteinsSeptember - Cell Scavengers Look to Take Bite Out of Infectious Disease
PNNL researchers use global proteomics to study macrophage response against Salmonella entericaAugust - On the Light Path to Bioenergy
High-sensitivity proteomics lead to discovery of operon in O2-producing proteinJuly - Targeting Toxins
NIH funding will help PNNL scientists develop assays to combat bioterrorismJuly - Matching Measurements Provide Most Complete Analysis of Salmonella to Date
Sample-matched transcriptomics and proteomics offer insight into organism's virulenceJune - TRAPping Proteins that Work Together Inside Living Cells
New way to probe for proteins working together reveals never-before-seen details of RNA polymerase in bacteriaJune - "Breathing" Bacterium's Role in Remediation
Imaging and surface science give better understanding of electron exchange in contaminant conversionJune - PNNL Plays Key Role in Pollution Health Risk Studies Led by OSU
Lab will provide pharmacokinetic model development, bioinformatics support, advisory roleJune - New Insights Gained About High-Risk Platelets from Diabetic Donors
Study identifies 122 proteins whose abundances differs in diabetic, non-diabetic plateletsMay - Energy Source Influences Found in Bacterium Immobilization of Radionuclides
A. dehalogenans makes technetium and uranium less mobile, less soluble, less riskyMay - Designer Protein Grabs Cover
Stable affinity reagent developed as antibody alternativeMay - Multiple Mechanisms Increase EGF Receptor Activity in Breast Cells
New understanding of breast tissue growth could provide novel drug targets for cancerMay - Nanotoxicology Research Gives Clues to Impact of Inhaling Particles
Combined capabilities identify how nanoparticles interact with lung cellsMay - Upregulated Protein Jumpstarts DNA Repair Process
Team discovers calmodulin levels reflect a specific cellular response to low-level radiationMay - Getting Molecules To Hold Still and Blink
New approach lets scientists trap single molecules and measure electron transfersApril - Something To Smile About
Pacific Northwest National Laboratory researchers elucidate first steps in tooth formationApril - New Methods Detect Radionuclides in Groundwater
Collaboration key on technetium-99 and strontium-90 sensingMarch - Iron Minerals Found in Subsurface Sediment Reduce Contaminant Oxidation, Mobility
Biogeochemistry research reveals potential role of iron-bearing micas in preventing technetium reoxidation and mobilization in the subsurfaceMarch - Visualizing Every Breath You Take
Magnetic resonance images of inhaled 3He gas provide first-ever pictures of complex airflow patterns in mammalian lungFebruary - Probe Gives Clearer, Real-Time Picture of Small Protein Changes
Multiuse affinity probe helps identify mechanisms for cell information transferFebruary - Better Bioremediation at Uranium Mill Tailings Site
Scientists find process that could enable sustained bioremediation of uraniumFebruary - Measurements at the Genome-Scale Made in Nanotoxicity Study
Macrophage cell model gives insight to toxic effects of nanomaterialsFebruary - Discovery Fleshes Out Metabolism of Key Environmental and Energy Bacteria
Results in Shewanella reveal new multi-protein enzyme in many bacterial speciesFebruary - Improved Protein Separations System Developed by PNNL and Biotech Firm
Tandem system uses antibodies from chicken eggs to find low-abundance proteins that indicate diseaseJanuary - Recent Patent Describes a New Method to Separate and Characterize Ions
Scientists' approach employs time-dependent electric field with novel waveform profilesJanuary
2009
Staff Awards and Honors
- First Book on FAIMS Published by PNNL Scientist
Field asymmetric waveform ion mobility spectrometry explored in CRC Press publicationDecember - Dick Smith Receives HUPO Award for Advancements in Proteomics Technologies
October - Wei-Jun Qian Receives New Innovator Award from NIH Director to Develop Dramatically Improved Biomarker Research and Clinical Diagnostic Tools
September - David Koppenaal Elected American Chemical Society Division Chair
September - Ultrasensitive ESI-MS Source and Interface wins R&D 100 Award
Achieving unprecedented analysis levels for human health studiesAugust - Dick Smith Named Editor-in Chief of Journal of Proteomics & Bioinformatics
June - Dick Smith named PNNL Inventor of the Year
May - Tim Scheibe Chosen Darcy Distinguished Lecturer
May - Josh Adkins Named to NIH Study Section
April - Changing Paradigm of Data-Intensive Computing Makes Journal Cover
February - Bill Morgan Named Scientific Director of NASA Summer School
February
2008
Research Highlights
- Linked Software Gives Better Picture of Organisms' Behavior
December - Check Out the Fundamental & Computational Sciences Achievements for 2008
December - Proteomics Research Makes Journal Top 20 List of Most Cited
November - Journal Cover Features De Novo Sequencing Approach for Identifying Proteins
Strategy combines unique sequence tags with spectrum analysis to characterize protein modifications.November - Taking a Systems Biology Approach to Infectious Disease Research
Five-year, $17 million program couples proteomics, bioinformatics and modeling to understand how infectious organisms workOctober - New Way to Study Electron Transfer Reactions Leads to Hot Paper, Journal Cover
Coupled method enables fluorescent dye use as a molecular probe to study electron transfer dynamics at single-molecule levelOctober - Photosynthesizing Bacteria with a Day-Night Cycle Contain Rare Chromosome
Novel linear chromosome of cyanobacterium harbors genes important for fuel productionSeptember - Science Going "Well" at Uranium Monitoring Site
Local reporters visit Integrated Field Research Challenge siteSeptember - Review Article Chronicles Research on Versatile Bacterium
Shewanella's role in carbon and metal cycling detailed in a special issue on the importance of microorganisms in sustainable developmentSeptember - New Data Analysis Tools Advance Protein Research
PNNL provides no-cost resources to scientists around the worldSeptember - New SPIN Corrals Protein Molecules
PNNL technology boosts mass spectrometer sensitivity and performanceAugust - Now It's Molecular: New Understanding of Radiation Effects on Cells
Scientists find altered mitochondria proteins in cells showing genomic instabilityAugust - New Technology Provides Accurate, Noninvasive Look at Microbial Metabolism
Data may help harness microbes to produce green fuelsJuly - Proteins Under Pressure
A little pressure in proteomics analyses squeezes four hours into a minuteJuly - Mobile Elements and Pseudogenes Identified in Shewanella Oneidensis MR-1
Newly discovered mobile elements provide a means of rapid evolution of bacterium important in contaminant and metal fate and transportJuly - Molecular-level Analyses Reveal Possible Mechanisms Underlying Parkinson's Disease
May - Protein Research Uncovers Surprising Similarities in Diverse Bacteria
Scientists use proteomics to reveal proteins commonly present in 17 different bacteriaMay - Assigning Proteins ID Cards
New approach identifies proteins with confidence, dropping false identifications to near zeroMay - Tissue proteomics targets blood test for breast cancer
May - Microbe-Metal Interaction Yields Novel Mineral Nanostructures
Nanotube-producing bacteria show manufacturing promiseApril - New Technology Enables Better Understanding of Brain Development
April - FCSD and EMSL Team to Develop a Transformational Next-Generation Proteomics Measurement Platform
April - Cavities Beware!
Real-time NMR technique may ultimately help characterize disease processes—including tooth decay—associated with bacterial biofilmsApril - Unlocking the Secrets of the Secretome
Findings may help researchers understand relationship between growth factor signaling and cancerApril - Biomarkers for Type 1 Diabetes Found Using Proteomics
Research highlighted in proteomic journalFebruary - X-ray Crystallography Reveals New Insights into Pentapeptide Repeat Protein Structure
Results may help us harness cyanobacteria to sequester carbonFebruary - New NMR Method to Characterize Proteins
A metal-amino acid motif is found to be involved in catalytic reactionFebruary - Proteins Provide Clues to Nanomaterial Toxicity
Adsorbed albumin influences biological activity of two kinds of nanomaterialsFebruary - Regulatory Protein Shown to Indicate Stress in Skeletal Muscle
Calmodulin points to factor contributing to inflammationJanuary - BioPilot: Data Intensive Computing for Complex Biological Systems
January
2008
Staff Awards and Honors
- Justin Teeguarden on NRC Nanomaterial Report Committee
December - Wei-Jun Qian Named "Rising Star" by Genome Technology
Magazine profiles the best up-and-coming young investigators, selected by the field's elite scientistsDecember - Dave Koppenaal to Serve on International Advisory Board for New Journal
November - Demand Continues for Bacterial Nanowire Article
October - Allan Konopka Joins Laboratory Fellow Ranks
August - Eminent Radiation Biology Researcher Joins PNNL
August - Karin Rodland selected as Laboratory Fellow
August - PNNL Researcher Named to NAS Nanoscience Review Committee
May - Tom Metz Named to Proteomic Insights Editorial Board
May - Metting Appointed to Fourth Term on Oregon Bioscience Association Board
May - Keqi Tang Chosen 2007 PNNL Inventor of the Year
April - Pounds and Weber Receive Appointments to Toxicology Society
April - International Scientific Collaboration Earns Honorary Professorship
April - Mass Spec Manuscript Heads Top 25 Hottest Articles List
March - Authors Clamor To Read, Cite Article on Nanowires in Bacteria
January
2007
Research Highlights
- Shewanella Shows Cytochromes Convert Contaminant
S. oneidensis outer membrane cytochromes make technetium less mobile, less soluble, less riskyDecember - Dick Smith Named to Prestigious 2007 Scientific American 50 List
Researchers use proteomics to understand the human brain in health and diseaseDecember - Compilation of Fundamental Science Accomplishments Now Available
December - Comprehensive Whole-Proteome Analysis Now Available to Scientific Community
Shows potential of mass-spec-based proteomics for improving genome and proteome annotationsNovember - Radionuclide Monitors Being Developed Through Partnership Between PNNL ERSP Researchers and Small Business
Field-deployable monitoring systems for strontium and technetium in Hanford site groundwaterOctober - NIH Funds New Biomarkers Center at PNNL
Center to identify biological response markers for chronic inflammatory stress to cigarette smoke and obesityOctober - A New Fluorescent Probe for Protein Interactions
Research published in JACS, highlighted in NatureJuly - Researchers Develop, Improve and Enhance Technologies for Rapid Analysis of Complex Samples
FAIMS/IMS is meeting the proteomics throughput challengeJune - New View on Radiation-Resistant Microbe
Deinococcus radiodurans work featured in PLoS BiologyJune - A New Systems Strategy to Study Cell Surface Receptor Dynamics
A novel computational approach to systems biology researchJune - First Comprehensive Profile of Cell Movement Created by PNNL, UCSD
Combined proteomics and phosphoproteomics approaches make it possibleMay - Nanobiotechnology Research Featured in Prominent Journals
Functionalized mesoporous silica wakes up inactive enzymesMay - Changes in Environmental Conditions Impact Cell Function
Scientists investigate enzyme that makes RNAApril - Improved Methods for Nanoparticle Toxicity Research
Work will lead to more accurate, more interpretable tests of potential health hazardsApril - 3-D Cultures Help Identify, Screen Noroviruses
Scientists develop successful in vitro cell culturingApril - Novel Trafficking Pathway Found for Heart and Muscle Protein
Live-cell imaging provides new insights into mechanisms that regulate heart diseaseMarch - Mass Spectrometry Capabilities Aid in Large Poxvirus Study
Results will help development of improved antiviral drugs and vaccinesMarch
2007
Staff Awards and Honors
- Dave Koppenaal Named AAAS Fellow
November - Dick Smith Elected to HUPO Council
November - Qian honored with Ronald L. Brodzinski Award for Early Career Exceptional Achievement
October - Romine Gives Seminar at 100th Genome Celebration
May - Konopka Named Microbiology Group Lead
March - Two Journal Articles Make ACS Most-Cited List
March - Vanessa Bailey Joins Editorial Board of Soil Biology and Biochemistry
March - Metting Named Chair of International Scientific Network
February
2006
Research Highlights
- PNNL to Manage Two DOE Field Research Sites for Studying Contaminant Transport
New program enables multidisciplinary research, data sharingDecember - Cytochrome Studies Provide Biofuel Cell Potential
Electrical charge measurements may point way to miniature biofuel cell developmentNovember - Studies of Corrosion-Causing Bacterium Shed New Light on Decay Mechanisms
Genomic, proteomics, and computational research on Desulfovibrio vulgaris give insight to the bug's metabolism for corrosion and inorganic contaminant immobilizationNovember - Plague Proteome Reveals Proteins Linked to Infection
November - PNNL, Agilent CRADA Sgned for Proteomic Research
Research will lead to more accurate protein and peptide identificationOctober - PNNL Wins Project BioShield Grants
Researchers to develop ways to counter radioactive materials from "dirty bombs"October - Chromate Immobilization Success Leads to More Field Tests for Effective, Long-Lived Contaminant Barriers
Results expected to protect humans, environment near Columbia RiverOctober - First Use of Global Proteomics to Quantify Bacterial Proteins Isolated from Host Cells
Systematic investigation of changes can identify proteins important to detecting bacterial pathogens and developing vaccinesOctober - PNNL Staff Support Breast Cancer Research Awareness
October - Novel Bug Work Appears in Two Journals
August - PNNL Featured in C&E News Sys Bio Cover Story
August - PNNL Scientists Improve Quality of Global Transcriptome Studies
August - Shewanella Uranium Reduction Role Described in PLoS Article
August - DOE Awards PNNL Contract for Single-Molecule Studies of Enzymes
August - Improved sensors developed for long-term groundwater monitoring at DOE sites
July - PNNL Team Makes the First Global Identification of Endogenous Levels of Nitrated Proteins in the Brain
July - Second Phase of PNNL Diabetes Research Funded by NIH
June - Combined Methods Meet Challenge of Studying Protein Changes
June - Illuminating the Mechanism of Fluorophore-assisted Light Inactivation of Proteins
June - Systems Biology Article Appears in The Scientist
June - Better Proteomic Measurements Achieved with Smaller Liquid Chromatography Columns
June - Isolation and Validation of a Metal-reducing Protein Complex from Shewanella published in the Journal of Bacteriology
June - New Insights Made into the Functioning of Deep Subsurface Microbial Communities
June - Open-source Software Tool for Protein Microarray Analysis Available from PNNL
June - Live Wires: A microbiologist discovers our planet is hard-wired with electricity-producing bacteria
June - New Role Discovered for Calmodulin: Modulating Inflammatory Response
June - Researchers develop improved protein affinity probe
May - Researchers Develop Improved Protein Affinity Probe
May - PNNL Wins NCI Contract for Breast Cancer Biomarker Research
April - Firsts in Mouse and Mammalian Brain Proteomic Research Featured in Journal
April - First Study on the Mitochondrial Outer Membrane Subproteome Appears in Proteomics
April - First Constraint-Based Metabolic Model for an Archaea to be Published in Nature Reviews Molecular Systems Biology
January
2006
Staff Awards and Honors
- Noted Radiation Biology Researcher Named PNNL Affiliate Scientist
December - Dick Smith Named AAAS Fellow
December - Jim Fredrickson Named AAAS Fellow
December - Proteomic Poster Wins Award at International Proteome Meeting
November - Adkins Honored with Lab Director's Award for Exceptional Achievement
October - Fredrickson Appointed to Mars Committee
July - Ellis Appointed to Canadian NMR Advisory Board
June - Hoyem Named PNNL Administrator of the Year
June - Ray Wildung Joins Biological and Environmental Research Advisory Committee
April - Fredrickson Named GTL Chief Scientist
February
2005
Research Highlights
- Cutting-edge proteomics tool featured in two Analytical Chemistry articles
December - Rodland speaks at breast cancer forum in Olympia
November - Mass spectrometry detectors—eye on ions
November - Low-dose work highlighted in three journal articles
November - Journal lists two PNNL articles in top five most accessed
November - Imaging system success story featured on journal cover
September - NMR technologies developed for biofilm studies featured in recent journals
September - Carbon tetrachloride and chloroform accumulate and resist migration in Hanford aquifer sediments
September - Ellis contributes to National Academies' report
September - Novel sensor for technetium applicable to Hanford and other DOE sites
September - DOE review of proteomic informatics capability given high marks
July - PNNL part of NIH protein production center contract
July - Simulation of PNNL protein identification process featured in journal special edition
July - Ultra-high performance separations and mass spectrometry work featured in IJMS
June - Automated, high-throughput protein pipeline in place at PNNL
June - NMR study of DNA repair protein dynamics featured on journal covers
June - PNNL receives NIH funding to model bacterial membrane proteins and human cell signaling networks
June - Study of rare tautomers featured on journal cover
May - A fluorescent probe finds a second use in a resin for protein pull-downs
May - New biological consortium featured in The Scientist
May - PNNL NCRR Proteomics Research Resource hosts national workshop
May - Collaborative research published in PNAS focuses on skeletal muscle cell understanding
May - PNNL sponsors seminar at annual AAAS meeting on high-throughput biological data
April - Shewanella profiling paper appears in PNAS
April - Proteomics Resource Advisory Committee held yearly meeting at EMSL
February - PNNL to play key role in RTK Consortium
February - Enhanced Soil Carbon Sequestration Evaluation Methods Reviewed in Journal Article
February - Identifying shed and secreted proteins by mass spectrometry after exposure of CHO cells to low-dose radiation
February - Enhanced yellow fluorescent protein enables definition of bystander-specific transformation response
January
2005
Staff Awards and Honors
- Wiley named AAAS Fellow
November - Wiley named to editorial board of The Scientist
September
2004
Research Highlights
- Cellular Response to Protein Nitration in C2C12 Myocytes Detected with Complementary Approaches: Cell Biology and Global Proteomic Screens
December - NABIR project demonstrates that uranium remains immobile one year after wells were injected with acetate
November - Mechanisms of 3D intercellular signaling in mammary epithelial cells in response to low dose, low-LET radiation: Implications for the radiation-induced bystander effect
November - PNNL to receive NIH contract for proteomic studies of potential therapeutic targets
October - Bystander Effects in Cells Exposed to Low Dose Radiation: Identifying Shed Proteins by Mass Spectrometry and Statistical Confidences
October - Pacific Northwest team unveils largest virus proteome to date
Findings reveal the human cytomegalovirus is even more complex than predictedSeptember - Peering inside the body, with a new spin-literally
September - PNNL lands $10.3 million NIH biodefense contract to unlock proteomes of salmonella and pox
5-year project will explore how our cells interact with infectious-agents and point the way to new, fast-acting drugsSeptember - NMR Spectroscopic Investigation of Human Carbonic Anhydrase Points to Alternative Mechanism of Action
July - Most complete human blood-plasma proteome to date
June