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Bioprocess Measurements Group

Welcome

The Bioprocess Measurements Group develops measurement methods and standards that support a variety of application areas, particularly those relevant to biological industrial processes. Areas of current active interest include: 

  • Standards & new methods for counting & characterizing protein particles in biotherapeutics
  • Novel sensors for monitoring health and industrial manufacture of biological products
  • Innovative device platforms and signal processing methods
  • Affinity-based assays of the glycosylation (sugar decoration) patterns in biotherapeutic proteins
  • Protein conformation studies, in solution and adsorbed to surfaces. 

We combine expertise in instrumentation science, nanomaterials, and chemical and physical characterization of surfaces, sensor materials, and biological molecules. 

Programs/Projects

Surface Characterization of Conjugated Gold Nanoparticles—This work examines the surface chemistry of conjugated gold nanoparticles, where the molecular modifiers are linked to the gold NP via a gold-sulfur bond, including obtaining information on the …

Rapid Measurement of Aggregation of Protein Therapeutics During Biomanufacturing—Protein therapeutics is the largest class of drugs made by the biotechnology industry. Aggregation of protein therapeutics is a major safety concern because aggregates can cause adverse, even …

Nanocalorimetry—Nanocalorimetry using micromachined devices has the capability to provide quantitative data to support the development of advanced metal silicide metallizations for semiconductor devices. The …

Chemical/Biochemical Microsensor Science—The Process Sensing Group at NIST is investigating a range of fundamental and technological issues related to next-generation chemical and biochemical measurements with solid state devices. A …

Selected Publications
Highlights

Affinity assay of biotherapeutic, rituximab, by a lectin, Con A

Credit: A. Dutta

Modified surface used to study the affinity binding of a protein therapeutic, Rituximab, with a lectin, Con A.


 
Contact

General Information:
Dr. Dean C. Ripple
301-975-4801 Telephone
301-975-2643 Facsimile

100 Bureau Drive, M/S 8362
Gaithersburg, MD 20899-8362