Workshop on Nitric Oxide as a Potential Therapeutic
Agent: Application to Sickle Cell Disease and Other Vascular Diseases
September 5-6, 2000 Lister Hill Auditorium
sponsored by the National Heart, Lung, and Blood Institute, the NIH
Office of Rare Diseases, and the National Institute of Diabetes, Digestive,
and Kidney Diseases
Tuesday, September 5, 2000
8:00 AM Continental Breakfast and Registration
8:30 Introduction
Dr. Steve
Groft, Director, NIH Office of Rare Diseases
Dr. Barbara
Alving, Director, DBDR, NHLBI
Dr. Greg
Evans, DBDR, NHLBI
8:35 Workshop Overview - Why Nitric Oxide
in Sickle Cell Disease, and Other Vascular Diseases?
Alan
Schechter, NIDDK,Workshop Chair
8:45 Session I. Nitric Oxide,
Circulatory Physiology, and Therapeutics (Warren Zapol, Chair)
8:50 Jay Zweier -
Measurement and Imaging of Nitric Oxide in Biological Tissues.
9:15 Harry Ischiropoulos
- Nitric Oxide Modification of Proteins
9:35 Warren Zapol -
Nitric Oxide Therapeutics
10:00 discussant - Mark
Gladwin
10:20 Break
10:40 Session II. Nitric Oxide and
Cardiovascular Diseases (Richard Cannon, Chair)
10:45 Richard Cannon -Vascular
Effects of Nitric Oxide Inhalation In Humans
11:10 Virginia Miller -
The Paradox of Estrogen Replacement: Arterial Protection Versus Venous
Thrombosis
11:35 Jonathan Abrams -
Nitric Oxide Donors in the Treatment of Cardiovascular Disease
12:00 Joe Vita - Effects
of Ascorbic Acid on Endothelial Vasomotor Function
12:25 discussant - Julio
Panza
12:45 Lunch, on your own
1:45 Session III. Nitric Oxide and
Lung Diseases (Serpil Erzurum, Chair)
1:45 Serpil
Erzurum - Endogenous Nitric Oxide and Nitric Oxide Reaction Products in the
Human Lung
2:10 Raed Dweik -
Oxygen Regulates Nitric Oxide Production in the Lungs
2:35 John Kinsella
- The Role of Inhaled Nitric Oxide in Premature Newborns and Bronchopulmonary
Dysplasia
3:00 Break
3:15 Steve Abman -
The Role of Inhaled Nitric Oxide Therapy in Neonatal Pulmonary Hypertension
3:40 Richard
Channick - Chronic Nitric Oxide Inhalation in Adult Patients with Pulmonary
Disorders
4:05 discussant -
Warren Zapol
4:25 Transportation to Doubletree Hotel
via Metro.
5:00 Poster Session at Doubletree
Hotel
7:00 Group Dinner at
Doubletree Hotel
After-dinner talk: Griffin Rodgers - Pathophysiology and Treatment of Sickle
Cell Disease
Wednesday, September 6, 2000
8:00 AM Continental Breakfast
8:30 Session III. Nitric Oxide and
the Kidney/Kidney Diseases (Josie Briggs, Chair)
8:35 Antonio
Guasch - Glomerular Effects of Nitric Oxide Inhibition in Humans
9:00 Chris Baylis
- Nitric Oxide Deficiency in Chronic Renal Disease
9:25 Chris Wilcox
- Nitric Oxide Deficiency in Hypertension
9:50 discussant -
Josie Briggs
10:10 Break
10:25 Session V. Nitric Oxide,
Hemoglobin, and Sickle Cell Disease (Greg Evans, Chair)
Nitric Oxide and Hemoglobin 10:30 David
Singel - Kinetics of the Oxyhemoglobin Reaction of Nitric Oxide
10:55 Jonathan Stamler -
Hemoglobin: a Microcosm of Nitric Oxide Biology
11:20 Celia Bonaventura
- Effects of S-Nitrosation on Oxygen Binding by Normal and Sickle Cell
Hemoglobin
11:45 Mark Gladwin -
Delivery of Nitric Oxide on Hemoglobin
12:10 Lunch, on your own
Nitric Oxide and Reactive Oxygen Species
1:10 Bruce Freeman - Oxidase and
Oxygenase Impairment of Endothelial-Dependent Function in Sickle Cell Disease
NO and Sickle Cell Disease 1:35 Marie
Stuart - Nitric Oxide and Endothelial Activation in Patients with Sickle Cell
Disease
2:00 Al Head -
Inhaled Nitric Oxide for the Treatment of Sickle Cell Disease
2:25 Alan
Schechter - Effect of Nitric Oxide In Vitro and In Vivo in Sickle Cell Disease
2:50 Break
3:05 Claudia
Morris - Clinical Studies of Nitric Oxide Donors in Sickle Cell Disease
3:30 discussant -
Marie Stuart
3:50 Workshop Summary (Alan
Schechter)
4:00 Recommendations from
participants for future research on nitric oxide as a therapeutic agent for
sickle cell disease and other
vascular diseases (Greg Evans)
4:15 ADJOURN
|