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DOE Hits Sequencing GoalJGI Strategies Pay Off for Chromosomes 5, 16, 19On April 13, the U.S. Secretary of Energy announced that researchers at the DOE Joint Genome Institute (JGI) had determined the draft sequence for human chromosomes 5, 16, and 19. The three contain more than 300 million bases or about 10% of the total human genome, with an estimated 10,000 to 15,000 genes. Some Disorders Linked to Genes on Chromosomes 5, 16, and 19
"These three chapters in the reference book of human life are nearly complete," said Energy Secretary Richardson. "Scientists already can mine this treasure trove of information for the advances it may bring in our basic understanding of life and in such applications as diagnosing, treating, and eventually preventing disease." JGI, now headed by Trevor Hawkins,* was established by DOE at Walnut Creek, California, in 1997. It is one of the largest publicly funded human genome sequencing centers in the world. JGI Sequencing Strategies Computational Analysis of Draft Data The Java-based Genome Channel browser developed at ORNL provides a view of genomic sequences, computational and experimental annotation, and related links. The HTML-based Genome Catalog includes genomic summary reports, gene and protein lists, homologies, and other Internet capabilities. Finishing the Draft to High Quality Bug Month Future Directions In October, JGI announced a collaboration to sequence the genome of Fugu rubripes (pufferfish). Joining JGI are the Institute for Molecular and Cell Biology (Chris Tan), U.K. HGMP Resource Centre (Greg Elgar), Molecular Sciences Institute (Sydney Brenner), and Institute for Systems Biology (Leroy Hood). Because of its strong similarity to the human genome in number of genes and control sequences, the Fugu genome is considered a powerful, compact tool for identifying these regions in the much larger human genome. Scientists expect to sequence more than 95% of Fugu by March 2001. Click here for continuing coverage at the JGI Website. *On November 3, DOE announced Trevor Hawkins' appointment as JGI director. JGI's first director Elbert Branscomb will assume leadership in developing the new OBEr program, Bringing the Genome to Life. The electronic form of the newsletter may be cited in the following style: |
Last modified: Wednesday, October 29, 2003
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