The proposed innovation is to apply unique optical fiber sensing elements and optical transduction principles to the early detection of microbial fouling. Critical to monitoring and maintaining the quality of recycled waters and assessing the effectiveness of new methods is the development of sensor… More

This Phase I proposal addresses the need to develop in situ, multi- element sensor arrays for nutrient solution analysis. Various macrocycle compounds have been shown to uniquely complex metal ions. The innovation is to use chromogenic macrocycle compounds, which are currently under development, and… More

Advances in the modern understanding and control of biological systems have been richly informed bystructure information at the scale of interatomic distances. In human health, the impact of moleculaorganismic dysfunction, e.g., genetic, metabolic, hematologic, and other disease, is strongly… More

Tissue pH is a good indicator of the poor blood flow/poor oxygenation condition called ischemia, and can be used to assess tissue viability. Polestar Technologies, Inc. proposes a program to develop a non-invasive tissue pH sensor and monitoring system which utilizes the intrinsic light absorbing… More

40958 November 19, 1996 Polestar Technologies, Inc. An instrument that can rapidly analyze soil samples in order to identify and quantify organic containments is needed for environmental monitoring and cleanup. This project will develop a portable… More

The goal of this Small Business Innovation Research project is to demonstrate a fluorescent glucose-indicator chemistry with high thermal stability for construction of an in situ optical glucose sensor to monitor the culture medium of continuous process bioreactors. The specific binding properties.… More

A Small Business Research (SBIR) project is proposed for development of an improved optical oxygen sensor for dissolved oxygen monitoring in the cell culture medium of continuous process bioreactors. The improved oxygen monitor will enable reliable long-term control of oxygen levels in continuous… More

This Phase I SBIR project will develop a high-precision, non-Invasive instrument for monitoring hematocrit. There exists a need to have an automated, continuous, and non-Invasive method of measuring hematocrit directly on the patient as a way to gauge blood loss of trauma victims and to evaluate the… More

Not Available The goal of this project is to define and pursue novel SAR processing techniques to exploit the phase history data to the full potential. Essex plans to augment traditional SAR processing capabilities by extending the resolution and bandwidth via a coherent combination of multiband,… More

Polestar Technologies, Inc., proposes to develop a field-portable gas chromatography/ Fourier transform infrared spectroscopy (GC/FTIR) instrument that is based on a novel infrared detection interface for the hyphenated GC/FTIR analysis technique. The new GC/FTIR interface will have substantial… More

65685 A deeper understanding of microbial processes and their physiological status in various soils and pore structures is needed in order to optimize bioremediation process. However, it is difficult to determine the influence of physical and/or geochemical forces on the efficiency of… More

In the Phase I program, an optically based instrument will be developed for in-situ monitoring of cell density in bioreactors used for manufacturing biopharmaceuticals. The cell density monitor employs a novel design integrating recent advances in opto-electronic technology to provide a… More

The proposed research will investigate the development of a new optical oxygen monitor for aircraft fuel tanks. A new chemically resistant sensing membrane is described which, when the used with fluorescence lifetime quenching, is expected to provide arobust, lightweight system capable of inherently… More

An optically based instrument for in-situ analysis of multiple chemical components in bioreactors will be developed and applied to monitor key components in hybridoma cell fermentation processed used for producing monoclonal antibodies. Monoclonal antibodies have become valuable agents for new… More

Polestar Technologies, Inc. proposes a Phase I Small Business Innovation Research project to demonstrate the feasibility of a compact optical monitor for continuous dissolved oxygen monitoring in areas at risk of eutrophication induced hypoxia and anoxia. The proposed monitor will facilitate the… More

Polestar Technologies, Inc. proposes a Phase II SBIR Project to complete the development of an inexpensive compact optical system for continuous dissolved oxygen monitoring in areas at risk of eutrophication induced by hypoxia and anoxia. The proposed monitor will facilitate the development of… More

DESCRIPTION (provided by applicant): There is a need for an in-situ cell density monitor to provide continuous measurement of mammalian cell density inside of disposable, pre-sterilized bag bioreactors which have become an important new type of cell culture vessel for the production of monoclonal… More

The exposure of perishable commodities to even modest levels of ethylene is known to significantly affect the quality and appearance of the product resulting in a reduction of shelf life and market value. A Phase I project is proposed which will demonstrate the feasibility of an innovative, low cost… More

DESCRIPTION (provided by applicant): There is a need for an in-situ multiple component chemical analyzer to provide periodic measurement of key nutrients and products in mammalian cell culture processes which are conducted in a variety of reactor vessels i ncluding roller bottles, T-flasks, shake… More

The objective of this program is to develop a stand-off detection system with a combined detection and chemical identification capability needed to detect and identify explosives hidden by a suicide bomber under his/her clothes. We aim to develop this unique system by fusing two orthogonal… More

The aim of this DARPA Adoption SBIR Phase II Proposal is to develop a hybrid silicon-based chip by integrating the two types of sensor arrays - electrochemical and molecular recognition sensor array. We will design and fabricate the first prototype chip with separate stand-alone electronics and… More

The Phase II effort is to be conducted to complete the development of a new ethylene monitor with a detection limit at or below critical levels for storage of perishable commodities. The research effort will help with the development of a new ethylene monitor for use with control systems to regulate… More

The objective of this program is to develop a stand-off detection system with a combined detection and chemical identification capability needed to detect and identify explosives hidden by a suicide bomber under his/her clothes. We aim to develop this unique system by fusing two orthogonal… More

The overall objective of this program is to develop an effective means for integrating enzymes onto an electrode in order to improve electron transfer and enzyme loading and stability. The approach is based on conformably coating a layer of functional polymer onto an arrayed multi-walled carbon… More

Polestar Technologies, Inc. proposes a Phase I SBIR project for the development of a new transcutaneous CO2 sensor to address the need for a noninvasive sensor that is capable of providing reads with the accuracy required for controlling mechanical ventilation during ambulatory care. The new sensor… More

The overall goal of this SBIR proposal is to develop a portable system for stand-off detection of concealed explosives. The system will produce images showing the presence of the explosives and have the ability to detect and identify different types of military explosives (like TNT, RDX, PETN) as… More