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Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis

This study has been completed.
Sponsor:
Information provided by:
Katholieke Universiteit Leuven
ClinicalTrials.gov Identifier:
NCT01282905
First received: January 24, 2011
Last updated: January 25, 2011
Last verified: January 2011
History of Changes
  Purpose

The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.


Condition
Ulcerative Colitis

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective
Official Title: Impact of the Mucosal Detoxification Mechanism of Hydrogen Sulphide on the Oxidation Pathway of Butyrate in Ulcerative Colitis

Resource links provided by NLM:

U.S. FDA Resources

Further study details as provided by Katholieke Universiteit Leuven:

Biospecimen Retention:   Samples With DNA

colon tissue


Enrollment: 106
Study Start Date: October 2008
Study Completion Date: December 2010
Groups/Cohorts
Healthy controls
Ulcerative colitis

  Eligibility

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population

IBD patients clinic (Universitaire Ziekenhuizen Leuven)

Criteria

Inclusion Criteria:

- Ulcerative colitis patients: patients diagnosed with ulcerative colitis

Exclusion Criteria:

  • Healthy controls: no diagnosis of inflammatory bowel diseases
  • Intake of antibiotics in the last month before the study
  Contacts and Locations
Please refer to this study by its ClinicalTrials.gov identifier: NCT01282905

Locations
Belgium
KULeuven
Leuven, Belgium
Sponsors and Collaborators
Katholieke Universiteit Leuven
Investigators
Principal Investigator: Kristin Verbeke, PhD Katholieke Universiteit Leuven
  More Information

No publications provided

Responsible Party: Prof. Kristin Verbeke, KULeuven
ClinicalTrials.gov Identifier: NCT01282905     History of Changes
Other Study ID Numbers: ML3999
Study First Received: January 24, 2011
Last Updated: January 25, 2011
Health Authority: Belgium: Ethics Committee

Additional relevant MeSH terms:
Colitis
Colitis, Ulcerative
Ulcer
Gastroenteritis
Gastrointestinal Diseases
 Digestive System Diseases
Colonic Diseases
Intestinal Diseases
Inflammatory Bowel Diseases
Pathologic Processes

ClinicalTrials.gov processed this record on September 26, 2012