Talking Glossary of Genetic Terms

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Lawrence C. Brody, Ph.D. defines Hybridization

Hybridization

HAHY bri di zey shuhn

Hybridization is the process of combining two complementary single-stranded DNA or RNA molecules and allowing them to form a single double-stranded molecule through base pairing. In a reversal of this process, a double-stranded DNA (or RNA, or DNA/RNA) molecule can be heated to break the base pairing and separate the two strands. Hybridization is a part of many important laboratory techniques such as polymerase chain reaction and Southern blotting.

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