Transdermal Estradiol in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Previous Hormone Therapy and Chemotherapy
Tracking Information | |||||
---|---|---|---|---|---|
First Received Date ICMJE | November 18, 2005 | ||||
Last Updated Date | March 8, 2010 | ||||
Start Date ICMJE | May 2005 | ||||
Primary Completion Date | November 2009 (final data collection date for primary outcome measure) | ||||
Current Primary Outcome Measures ICMJE |
Decrease of 50% in PSA [ Designated as safety issue: No ] | ||||
Original Primary Outcome Measures ICMJE |
Decrease of 50% in PSA | ||||
Change History | Complete list of historical versions of study NCT00255632 on ClinicalTrials.gov Archive Site | ||||
Current Secondary Outcome Measures ICMJE | |||||
Original Secondary Outcome Measures ICMJE | |||||
Current Other Outcome Measures ICMJE | |||||
Original Other Outcome Measures ICMJE | |||||
Descriptive Information | |||||
Brief Title ICMJE | Transdermal Estradiol in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to Previous Hormone Therapy and Chemotherapy | ||||
Official Title ICMJE | A Phase II Trial of Climara Transdermal Estradiol in Patients With Hormone Refractory Prostate Cancer | ||||
Brief Summary | RATIONALE: Testosterone can cause the growth of prostate cancer cells. Hormone therapy using estradiol may fight prostate cancer by lowering the amount of testosterone the body makes. PURPOSE: This phase II trial is studying how well transdermal estradiol works in treating patients with metastatic prostate cancer that did not respond to previous hormone therapy and chemotherapy. |
||||
Detailed Description | OBJECTIVES: Primary
Secondary
OUTLINE: Patients wear 4 transdermal estradiol patches (Climara^®) continuously. All patches are changed every 7 days. Treatment continues in the absence of disease progression or unacceptable toxicity. Quality of life is assessed at baseline, every 3 weeks during study treatment, and at completion of study treatment. PROJECTED ACCRUAL: A total of 33 patients will be accrued for this study. |
||||
Study Type ICMJE | Interventional | ||||
Study Phase | Phase 2 | ||||
Study Design ICMJE | Masking: Open Label Primary Purpose: Treatment |
||||
Condition ICMJE | Prostate Cancer | ||||
Intervention ICMJE | Biological: therapeutic estradiol | ||||
Study Arm (s) | |||||
Publications * | |||||
* Includes publications given by the data provider as well as publications identified by ClinicalTrials.gov Identifier (NCT Number) in Medline. |
|||||
Recruitment Information | |||||
Recruitment Status ICMJE | Completed | ||||
Estimated Enrollment ICMJE | 33 | ||||
Completion Date | November 2009 | ||||
Primary Completion Date | November 2009 (final data collection date for primary outcome measure) | ||||
Eligibility Criteria ICMJE | DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS: Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Cardiovascular
Pulmonary
Other
PRIOR CONCURRENT THERAPY: Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Other
|
||||
Gender | Male | ||||
Ages | 18 Years and older | ||||
Accepts Healthy Volunteers | No | ||||
Contacts ICMJE | Contact information is only displayed when the study is recruiting subjects | ||||
Location Countries ICMJE | United States | ||||
Administrative Information | |||||
NCT Number ICMJE | NCT00255632 | ||||
Other Study ID Numbers ICMJE | 080419; CDR0000445280, P30CA072720, CINJ-080419-5247 | ||||
Has Data Monitoring Committee | Yes | ||||
Responsible Party | Mark Stein, Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School | ||||
Study Sponsor ICMJE | University of Medicine and Dentistry New Jersey | ||||
Collaborators ICMJE | National Cancer Institute (NCI) | ||||
Investigators ICMJE |
|
||||
Information Provided By | University of Medicine and Dentistry New Jersey | ||||
Verification Date | March 2010 | ||||
ICMJE Data element required by the International Committee of Medical Journal Editors and the World Health Organization ICTRP |