Committee on Commerce & Manufacturing (1816-1825)
- William Hunter (F-RI) 1816-1817
- Nathan Sanford (R-NY) 1817-1820
- Mahlon Dickerson (R-NJ) 1820-1825
Committee on Commerce (1825-1927)
- James Lloyd (NR-MA) 1825-1826
- Josiah Johnston (NR-LA) 1826-1827
- Levi Woodbury (D-NH) 1827-1831
- John Forsyth (D-GA) 1831-1832
- William R. King (D-AL) 1832-1833
- Nathaniel Silsbee (W-MA) 1833-1835
- John Davis (W-MA) 1835-1836
- William R. King (D-AL) 1836-1841
- Jabez Huntington (W-CT) 1841-1845
- William Haywood (D-NC) 1845-1846
- John Dix (D-NY) 1846-1849
- Hannibal Hamlin (D-ME) 1849-1856
- Henry Dodge (D-WI) 1856-1857
- Clement Clay (D-AL) 1857-1861
- Zachariah Chandler (R-MI) 1861-1875
- Roscoe Conkling (R-NY) 1875-1879
- John B. Gordon (D-GA) 1879-1880
- Matt Ransom (D-GA) 1880-1881
- Samuel J. R. McMillan (R-MN) 1881-1887
- William P. Frye (R-ME) 1887-1893
- Matt Ransom (D-NC) 1893-1895
- William P. Frye (R-ME) 1895-1911
- Knute Nelson (R-MN) 1911-1913
- James P. Clarke (D-AR) 1913-1916
- Duncan U. Fletcher (D-FL) 1916-1919
- Wesley L. Jones (R-WA) 1919-1930
- Hiram W. Johnson (R-CA) 1930-1933
- Hubert D. Stephens (D-MS) 1933-1935
- Royal S. Copeland (D-NY) 1935-1939
- Josiah W. Bailey (D-NC) 1939-1947
Committee on Interstate Commerce (1887-1947)
- Shelby M. Cullom (R-IL) 1887-1893
- Matthew Butler (D-SC) 1893-1895
- Shelby M. Cullom (R-IL) 1895-1901
- Stephen Elkins (R-WV) 1901-1911
- Moses E. Clapp (R-MN) 1911-1913
- Francis G. Newlands (D-NV) 1913-1917
- Ellison D. Smith (D-SC) 1917-1919
- Albert B. Cummins (R-IA) 1919-1924
- Ellison D. Smith (D-SC) 1924-1925
- James E. Watson (R-IN) 1925-1928
- James Couzens (R-MI) 1928-1933
- Clarence C. Dill (D-WA) 1933-1935
- Burton K. Wheeler (D-MT) 1935-1947
Committee on Interstate and Foreign Commerce (1947-1961)
- Wallace H. White, Jr. (R-ME) 1947-1949
- Edwin C. Johnson (D-CO) 1949-1953
- Charles W. Tobey (R-NH) 1953
- John W. Bricker (R-OH) 1953-1955
- Warren G. Magnuson (D-WA) 1955-1961
Committee on Commerce (1961-1977)
- Warren G. Magnuson (D-WA) 1961-1977
Committee on Commerce, Science & Transportation (1977-Present)
- Warren G. Magnuson (D-WA) 1977-1978
- Howard W. Cannon (D-NV) 1978-1981
- Bob Packwood (R-OR) 1981-1985
- John Danforth (R-MO) 1985-1987
- Ernest F. Hollings (D-SC) 1987-1995
- Larry Pressler (R-SD) 1995-1997
- John McCain (R-AZ) 1997-2001
- Ernest F. Hollings (D-SC) 2001
- John McCain (R-AZ) 2001
- Ernest F. Hollings (D-SC) 2001-2003
- John McCain (R-AZ) 2003-2005
- Ted Stevens (R-AK) 2005-2007
- Daniel K. Inouye (D-HI) 2007-2009
- John D. Rockefeller IV (D-WV) 2009-Present