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Check out Molecular Psychiatry's recently published paper on stress-induced depression, co-authored by Nobel Laureate Paul Greengard!

Molecular Psychiatry was mentioned: A study published in Molecular Psychiatry provides evidence that children with lower socioeconomic status are more prone to mental illness. This study could with the development of strategies and personalized treatment for mental illness. Read the article or the news story!

An Immediate Communication in Molecular Psychiatry reports a molecular mechanism whereby NMDA receptor antagonists such as ketamine can increase mTOR signaling to elicit antidepressant actions. Drugs selectively targeting components of this pathway may offer novel approaches to the treatments of depression. Read the report now.

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TOP TEN MOST VIEWED PAPERS

The Top Ten charts the articles that have been downloaded most often over the previous 30 days, in HTML and PDF format, from the Molecular Psychiatry website. The chart does not rank the quality, scientific significance or citation impact of the content. However, it may bring articles to your attention that you might not have otherwise noticed. We hope you enjoy them.

January 2017

1. Gestational vitamin D deficiency and autism-related traits: the Generation R Study

   A A E Vinkhuyzen, D W Eyles, T H J Burne, L M E Blanken, C J Kruithof, F Verhulst, V W Jaddoe, H Tiemeier & J J McGrath

   doi:10.1038/mp.2016.213

   Abstract | Full Text | PDF

2. The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm

   J E LeDoux, J Moscarello, R Sears & V Campese

   doi:10.1038/mp.2016.166

   Abstract | Full Text | PDF

3. Genetics and intelligence differences: five special findings

   R Plomin & I J Deary

   doi:10.1038/mp.2014.105

   Abstract | Full Text | PDF

4. Folinic acid improves verbal communication in children with autism and language impairment: a randomized double-blind placebo-controlled trial

   R E Frye, J Slattery, L Delhey, B Furgerson, T Strickland, M Tippett, A Sailey, R Wynne, S Rose, S Melnyk, S Jill James, J M Sequeira & E V Quadros

   doi:10.1038/mp.2016.168

   Abstract | Full Text | PDF

5. Patient-specific models of microglia-mediated engulfment of synapses and neural progenitors

   C M Sellgren, S D Sheridan, J Gracias, D Xuan, T Fu & R H Perlis

   doi:10.1038/mp.2016.220

   Abstract | Full Text | PDF

6. Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment

   A Lacour, A Espinosa, E Louwersheimer, S Heilmann, I Hernández, S Wolfsgruber, V Fernández, H Wagner, M Rosende-Roca, A Mauleón, S Moreno-Grau, L Vargas, Y A L Pijnenburg, T Koene, O Rodríguez-Gómez, G Ortega, S Ruiz, H Holstege, O Sotolongo-Grau, J Kornhuber, O Peters, L Frölich, M Hüll, E Rüther, J Wiltfang, M Scherer, S Riedel-Heller, M Alegret, M M Nöthen, P Scheltens, M Wagner, L Tárraga, F Jessen, M Boada, W Maier, W M van der Flier, T Becker, A Ramirez & A Ruiz

   doi:10.1038/mp.2016.18

   Abstract | Full Text | PDF

7. From gut dysbiosis to altered brain function and mental illness: mechanisms and pathways

   G B Rogers, D J Keating, R L Young, M-L Wong, J Licinio & S Wesselingh

   doi:10.1038/mp.2016.50

   Abstract | Full Text | PDF

8. Structural dysconnectivity of key cognitive and emotional hubs in young people at high genetic risk for bipolar disorder

   G Roberts, A Perry, A Lord, A Frankland, V Leung, E Holmes-Preston, F Levy, R K Lenroot, P B Mitchell & M Breakspear

   doi:10.1038/mp.2016.216

   Abstract | Full Text | PDF

9. Novel osmotin inhibits SREBP2 via the AdipoR1/AMPK/SIRT1 pathway to improve Alzheimer’s disease neuropathological deficits

   S A Shah, G H Yoon, S S Chung, M N Abid, T H Kim, H Y Lee & M O Kim

   doi:10.1038/mp.2016.23

   Abstract | Full Text | PDF

10. Myelination of parvalbumin interneurons: a parsimonious locus of pathophysiological convergence in schizophrenia

    J Stedehouder & S A Kushner

    doi:10.1038/mp.2016.147

    Abstract | Full Text | PDF