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ToxCast Phase I
Science and Technology
pesticide, Toxicology, ToxCast, pollutant, ...
Background: Chemical toxicity testing is being transformed by advances in biology and computer modeling, concerns over animal use and the thousands of environmental chemicals lacking toxicity data. EPA's ToxCast program aims to address these concerns by screening and prioritizing chemicals for potential human toxicity using in vitro assays and in silico approaches. Objectives: This project aims to evaluate the use of in vitro assays for understanding the types of molecular and pathway perturbations caused by environmental chemicals and to build initial prioritization models of in vivo toxicity. Methods: We tested 309 mostly pesticide active chemicals in 467 assays across 9 technologies, including high-throughput cell-free assays and cell-based assays in multiple human primary cells and cell lines, plus rat primary hepatocytes. Both individual and composite scores for effects on genes and pathways were analyzed. Results: Chemicals display a broad spectrum of activity at the molecular and pathway levels. Many expected interactions are seen, including endocrine and xenobiotic metabolism enzyme activity. Chemicals range in promiscuity across pathways, from no activity to affecting dozens of pathways. We find a statistically significant inverse association between the number of pathways perturbed by a chemical at low in vitro concentrations and the lowest in vivo dose at which a chemical causes toxicity. We also find associations between a small set in vitro assays and rodent liver lesion formation. Conclusions: This approach promises to provide meaningful data on the thousands of untested environmental chemicals, and to guide targeted testing of environmental contaminants.
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3 views
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2.
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Toxics Release Inventory Chemical Hazard Information Profiles (TRI-CHIP) Dataset
Geography and Environment
TRI-CHIP, risk, inventory, TRI, IRIS, pollutant, ...
The Toxics Release Inventory (TRI) Chemical Hazard Information Profiles (TRI-CHIP) dataset contains hazard information about the chemicals reported in TRI. Users can use this XML-format dataset to create their own databases and hazard analyses of TRI chemicals. The hazard information is compiled from a series of authoritative sources including the Integrated Risk Information System (IRIS). The dataset is provided as a downloadable .zip file that when extracted provides XML files and schemas for the hazard information tables.
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4 views
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3.
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SITE COMPREHENSIVE LISTING (CERCLIS) (Superfund) - NPL Sites
Geography and Environment
Comprehensive Environmental Response Compensation ...
National Priorities List (NPL) Sites - The Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) ("Superfund") Public Access Database contains a selected set of non-enforcement confidential information and is updated by the regions every 90 days. The data describes what has happened at Superfund sites prior to this quarter (updated quarterly). This database includes lists of involved parties (other Federal Agencies, states, and tribes), Human Exposure and Ground Water Migration, and Site Wide Ready for Reuse, Construction Completion, and Final Assessment Decision (GPRA-like measures) for fund lead sites. Other information that is included has been included only as a service to allow public evaluations utilizing this data. EPA does not have specific Data Quality Objectives for use of the data. Independent Quality Assessments may be made of this data by reviewing the QAPP
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3 views
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4.
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SITE COMPREHENSIVE LISTING (CERCLIS) - Contaminants at CERCLIS (Superfund) Sites
Geography and Environment
Comprehensive Environmental Response Compensation ...
Contaminants at Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) ("Superfund") Sites - The CERCLIS Public Access Database contains a selected set of non-enforcement confidential information and is updated by the regions every 90 days. The data describes what has happened at Superfund sites prior to this quarter (updated quarterly). This database includes lists of involved parties (other Federal Agencies, states, and tribes), Human Exposure and Ground Water Migration, and Site Wide Ready for Reuse, Construction Completion, and Final Assessment Decision (GPRA-like measures) for fund lead sites. Other information that is included has been included only as a service to allow public evaluations utilizing this data. EPA does not have specific Data Quality Objectives for use of the data. Independent Quality Assessments may be made of this data by reviewing the Quality Assurance Action Plan (QAPP ).
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1 view
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5.
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SITE COMPREHENSIVE LISTING (CERCLIS) (Superfund)
Geography and Environment
Comprehensive Environmental Response Compensation ...
The Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) ("Superfund") Public Access Database contains a selected set of non-enforcement confidential information and is updated by the regions every 90 days. The data describes what has happened at Superfund sites prior to this quarter (updated quarterly). This database includes lists of involved parties (other Federal Agencies, states, and tribes), Human Exposure and Ground Water Migration, and Site Wide Ready for Reuse, Construction Completion, and Final Assessment Decision (GPRA-like measures) for fund lead sites. Other information that is included has been included only as a service to allow public evaluations utilizing this data. EPA does not have specific Data Quality Objectives for use of the data. Independent Quality Assessments may be made of this data by reviewing the Quality Assurance Action Plan (QAPP).
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1 view
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6.
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SITE COMPREHENSIVE LISTING (CERCLIS) (Superfund) - Responsible Parties at CERCLIS Sites
Geography and Environment
non-NPL, ...
Responsible Parties at CERCLIS Sites - The Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) ("Superfund") Public Access Database contains a selected set of non-enforcement confidential information and is updated by the regions every 90 days. The data describes what has happened at Superfund sites prior to this quarter (updated quarterly). This database includes lists of involved parties (other Federal Agencies, states, and tribes), Human Exposure and Ground Water Migration, and Site Wide Ready for Reuse, Construction Completion, and Final Assessment Decision (GPRA-like measures) for fund lead sites. Other information that is included has been included only as a service to allow public evaluations utilizing this data. EPA does not have specific Data Quality Objectives for use of the data. Independent Quality Assessments may be made of this data by reviewing the Quality Assurance Action Plan (QAPP).
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1 view
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7.
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SITE COMPREHENSIVE LISTING (CERCLIS) (Superfund) - Non-NPL Sites
Geography and Environment
non-NPL, ...
Non-NPL Sites - The Comprehensive Environmental Response, Compensation and Liability Information System (CERCLIS) ("Superfund") Public Access Database contains a selected set of non-enforcement confidential information and is updated by the regions every 90 days. The data describes what has happened at Superfund sites prior to this quarter (updated quarterly). This database includes lists of involved parties (other Federal Agencies, states, and tribes), Human Exposure and Ground Water Migration, and Site Wide Ready for Reuse, Construction Completion, and Final Assessment Decision (GPRA-like measures) for fund lead sites. Other information that is included has been included only as a service to allow public evaluations utilizing this data. EPA does not have specific Data Quality Objectives for use of the data. Independent Quality Assessments may be made of this data by reviewing the Quality Assurance Action Plan (QAPP).
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0 views
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8.
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1993 Toxics Release Inventory data for the state of California
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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106 views
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9.
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Chesapeake Bay Program Water Quality Database
Geography and Environment
biology, salinity, indicators, toxic, biological, ...
The Chesapeake Information Management System (CIMS), designed in 1996, is an integrated, accessible information management system for the Chesapeake Bay Region. CIMS is an organized, distributed library of information and software tools designed to increase basin-wide public access to Chesapeake Bay information. The information delivered by CIMS includes technical and public information, educational material, environmental indicators, policy documents, and scientific data. Through the use of relational databases, web-based programming, and web-based GIS a large number of Internet resources have been established. These resources include multiple distributed on-line databases, on-demand graphing and mapping of environmental data, and geographic searching tools for environmental information. Baseline monitoring data, summarized data and environmental indicators that document ecosystem status and trends, confirm linkages between water quality, habitat quality and abundance, and the distribution and integrity of biological populations are also available. One of the major features of the CIMS network is the Chesapeake Bay Program's Data Hub, providing users access to a suite of long- term water quality and living resources databases. Chesapeake Bay mainstem and tidal tributary water quality, benthic macroinvertebrates, toxics, plankton, and fluorescence data can be obtained for a network of over 800 monitoring stations.
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9 views
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10.
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Clean Air Status and Trends Network (CASTNET): Ozone
Geography and Environment
public health, Ozone, environment, ...
8-hour daily maximum ozone concentrations as measured by the Clean Air Status and Trends Network (CASTNET)
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8 views
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11.
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KMZ file of EPA Ambient Ozone Monitors
Geography and Environment
public health, ambient air, Ozone, environment, ...
A KMZ file with the location of all the EPA ambient ozone monitors with the ability to download data from within the description box.
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2 views
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12.
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1990 Toxics Release Inventory data for the state of Massachusetts
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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20 views
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13.
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Air Quality System (AQS) ambient observations: 2007 ozone
Geography and Environment
public health, ambient air, Ozone, environment, ...
Ambient ozone concentrations for 2007 from the national ambient air quality monitoring networks stored in the Air Quality System (AQS).
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2 views
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14.
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Green Vehicle Guide Data Downloads
Transportation
trucks, vehicle pollution, new auto, large cars, ...
The U.S. Environmental Protection Agency's Green Vehicle Guide provides vehicle ratings based on emissions and fuel economy. The downloadable data are available in text or spreadsheet (XLS) formats.
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4 views
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15.
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1999 Toxics Release Inventory data for the state of Alabama
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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10 views
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16.
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Conservation Effects Assessment Project (CEAP) Cropland Baseline Conservation Condition for Upper Mississippi River Basin
Agriculture
environmental effects, nutrient loss, ...
The dataset consists of estimates of erosion, sediment loss, soil organic carbon, nutrient loss, and pesticide loss from a statistically selected set of sample points within the Upper Mississippi River Basin. Results for the Baseline Conservation Condition are reported for the region as a whole and for each of the 14 subbasins within the region.
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5 views
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17.
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1987 Toxics Release Inventory data for the state of Georgia
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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6 views
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18.
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AirNow Real Time Air Quality KML File
Geography and Environment
public health, Air Quality, ambient air, AQI, ...
A KML file with the location of all real time air quality monitors and the current conditions (air quality index).
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4 views
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19.
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ACRES - Brownfields Properties
Geography and Environment
public health, xml, environment, ...
Brownfields are real property, the expansion, redevelopment, or reuse of which may be complicated by the presence or potential presence of a hazardous substance, pollutant or contaminant. This dataset shows the locations of sites, facilities and properties that have been contaminated by hazardous materials and are being, or have been, cleaned up under EPA Brownfields cleanup programs.
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4 views
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20.
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1987 Toxics Release Inventory data for American Samoa
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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4 views
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21.
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DOE Green Energy (R&D Results) Data Service
Science and Technology
sustainable energy, clean technologies, wave power, ...
Contains bibliographic data for research and development results relating to various forms of green energy, including solar, wind, tidal, bioenergy, and others, resulting from sponsored research by the Department of Energy and predecessor agencies. Default request returns first twenty-five records. See Technical Documentation for instructions on obtaining additional records. This data service allows the downloading of bibliographic records in formats that can be used to load the records into other databases or search tools. To search the DOE Green Energy Portal, use the Agency Program Page below.
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3 views
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22.
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DOE Green Energy (Patents) Data Service
Science and Technology
sustainable energy, clean technologies, wave power, ...
Contains bibliographic data for patents relating to various forms of green energy, including solar, wind, tidal, bioenergy, and others, resulting from sponsored research by the Department of Energy and predecessor agencies. Default request returns first twenty-five records. See Technical Documentation for instructions on obtaining additional records. This data service allows the downloading of bibliographic records in formats that can be used to load the records into other databases or search tools. To search the DOE Green Energy Portal, use the Agency Program Page below.
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2 views
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23.
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1987 Toxics Release Inventory data for the state of Arkansas
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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3 views
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24.
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Clean Air Markets Clean Air Interstate Rule (CAIR) NOx Ozone Season Program Allowance Holdings
Geography and Environment
NOx, Air Quality, AQ, power plants, ...
Current allowance holdings for entities regulated under CAIR NOx Ozone Season cap and trade program ... power plants and other facilities
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0 views
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25.
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1994 Toxics Release Inventory data for the District of Columbia
Geography and Environment
TRI State Data, TRI Data, PBT, ...
Toxics Release Inventory Data. The Toxics Release Inventory (TRI) is a publicly available EPA database that contains information on toxic chemical releases and waste management activities reported annually by facilities in certain industries as well as federal facilities.
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3 views
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