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Dr.H Varmus's lab used TissueScan in a recent publication in Oncogene (2009)
MYC-induced myeloid leukemogenesis is accelerated by all six members of the antiapoptotic BCL family
"Using TissueScan oncology survey panel from Origene, we performed quantitative real-time PCR analysis on cDNA acquired from 60 different tissues and tumor samples. Following quantitative real-time PCR analysis, we observed elevated levels of BFL1 in eight of nine breast tumor samples and three of nine colon tumor samples, compared to the normal tissue controls. Increased BCL2 expression was also detected in seven of the nine breast cancer samples, and BCLxl was overexpressed in a number of ovarian tumors."
ß-Arrestin/Ral Signaling Regulates Lysophosphatidic Acid–Mediated Migration and Invasion of Human Breast Tumor Cells, Mol. Cancer Res., Jul 2009; 7: 1064 - 1077. Breast Cancer Panel II
A primate subfamily of galectins expressed at the maternal–fetal interface that promote immune cell death, PNAS, Jun 2009; 106: 9731 - 9736. Human major Tissue Panel (HMRT102)
Adenosine A2A receptor is a unique angiogenic target of HIF-2 in pulmonary endothelial cells, PNAS, Jun 2009; 106: 10684 - 10689. Lung Cancer Panel I and IV
See all citations on TissueScan
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OriGene has the largest human cancer biorepository for biomarker discovery and validation. Since the year 2000 the company has invested over $20 million in this biorepository, resulting in over 140,000 human biospecimens representing over 12,000 donor cases.
