Study Summary: |
This study aims to better understand the metabolic changes in children that precede the development of type 2 diabetes, and the influence of Asian ethnicity on diabetes risk, by describing 1) metabolic changes and adipose factors associated. with the insulin resistance metabolic syndrome in prepubertal children; 2) the relationship between pancreatic islet B-cell function and family history of type 2 diabetes; 3) changes in these factors as children progress through puberty; 4) the relationship of diet and physical activity to the metabolic and adipose factors; and 5) the relationship between Japanese ancestry and metabolic, adipose, and insulin secretion factors. It proposes a longitudinal cohort study of 450 prepubertal (8-10 year old) nondiabetic Japanese-American and Caucasian children. Measurements at baseline and 2 year follow-up would include: lipids and LDL particle size, insulin, C-peptide, proinsulin, glucose tolerance and insulin secretion determined by an intravenous glucose tolerance test, plasminogen activator inhibitor-1, fibrinogen, Creactive protein, insulin- like growth factor-1 and insulin-like growth factor binding protein-3, body composition by DEXA, and intra-abdominal fat by MRI. |