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Effects of a Single Dose of Dextroamphetamine in Attention Deficit
Hyperactivity Disorder: A Functional Magnetic Resonance Study
Requesting IRB: |
National Institute of Mental Health |
Study Summary: |
The above-referenced research protocol proposes to study the effects of a single 10 mg dose of dextroamphetamine in conjunction with functional magnetic resonance imaging in healthy children and children with attention deficit hyperactivity disorder (ADHD), all between 9 and 18 years of age. The overall goal of the proposed study is to better understand the pathophysiology of ADHD. The specific aims of the study are to: (i) study brain activation patterns during response inhibition tasks in children with ADHD and in healthy controls; (ii) simultaneously examine the central and behavior effects of a single-dose of amphetamine versus placebo in the two groups; and (iii) examine (using monozygotic and dizygotic twins) brain activation patterns in relation to clinical state and the degree of genetic relatedness. |
Funding Source: |
National Institute of Mental Health, National Institutes of Health |
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Informed consent (adult) and assent (child/minor)
IRB Documents
Federal Register Notices
Panel of Experts Transcripts
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