Our Science – McVicar Website

Daniel W. McVicar, Ph.D.

Selected Publications

1) Gómez-Rodríguez J, Washington V, Cheng J, Dutra A, Pak E, Liu P, McVicar DW, Schwartzberg PL.
Advantages of q-PCR as a method of screening for gene targeting in mammalian cells using conventional and whole BAC-based constructs.
Nucleic Acids Res. 2008. [Journal]

2) Whittaker GC, Burshtyn DN, Orr SJ, Quigley L, Hodge DL, Pascal V, Zhang W, McVicar DW.
Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire.
Blood. 112: 2869-77, 2008. [Journal]

3) Thomas R, Yamada E, Alter G, Martin MP, Bashirova AA, Norman PJ, Altfeld M, Parham P, Anderson SK, McVicar DW, Carrington M.
Novel KIR3DL1 alleles and their expression levels on NK cells: convergent evolution of KIR3DL1 phenotype variation?.
J. Immunol. 180: 6743-50, 2008. [Journal]

4) Yamada E, McVicar DW.
Paired receptor systems of the innate immune system.
Current protocols in immunology / edited by John E. Coligan ... [et al.]. Chapter 1: Appendix 1X, 2008. [Journal]

5) Nurden AT, Nurden P, Bermejo E, CombriÃ© R, McVicar DW, Washington AV.
Phenotypic heterogeneity in the gray platelet syndrome extends to the expression of TREM family member, TLT-1.
Thromb. Haemost. 100: 45-51, 2008. [Journal]

6) McVicar DW.
Rafting with the IL-12 receptor.
Blood. 111: 3911-2, 2008. [Journal]

7) Orr SJ, Morgan NM, Elliott J, Burrows JF, Scott CJ, McVicar DW, Johnston JA.
CD33 responses are blocked by SOCS3 through accelerated proteasomal-mediated turnover.
Blood. 109: 1061-8, 2007. [Journal]

8) Thananchai H, Gillespie G, Martin MP, Bashirova A, Yawata N, Yawata M, Easterbrook P, McVicar DW, Maenaka K, Parham P, Carrington M, Dong T, Rowland-Jones S.
Cutting Edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B.
J. Immunol. 178: 33-7, 2007. [Journal]

9) Pascal V, Yamada E, Martin MP, Alter G, Altfeld M, Metcalf JA, Baseler MW, Adelsberger JW, Carrington M, Anderson SK, McVicar DW.
Detection of KIR3DS1 on the cell surface of peripheral blood NK cells facilitates identification of a novel null allele and assessment of KIR3DS1 expression during HIV-1 infection.
J. Immunol. 179: 1625-33, 2007. [Journal]

10) Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, McVicar DW.
Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1.
Thromb. Haemost. 97: 955-63, 2007. [Journal]

11) Martin MP, Qi Y, Gao X, Yamada E, Martin JN, Pereyra F, Colombo S, Brown EE, Shupert WL, Phair J, Goedert JJ, Buchbinder S, Kirk GD, Telenti A, Connors M, O'Brien SJ, Walker BD, Parham P, Deeks SG, McVicar DW, Carrington M.
Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1.
Nat. Genet. 39: 733-40, 2007. [Journal]

12) Gillespie GM, Bashirova A, Dong T, McVicar DW, Rowland-Jones SL, Carrington M.
Lack of KIR3DS1 binding to MHC class I Bw4 tetramers in complex with CD8+ T cell epitopes.
AIDS Res. Hum. Retroviruses. 23: 451-5, 2007. [Journal]

13) Mason LH, Willette-Brown J, Taylor LS, McVicar DW.
Regulation of Ly49D/DAP12 signal transduction by Src-family kinases and CD45.
J. Immunol. 176: 6615-23, 2006. [Journal]

14) Bashirova AA, Martin MP, McVicar DW, Carrington M.
The Killer Immunoglobulin-Like Receptor Gene Cluster: Tuning the Genome for Defense (*).
Annu Rev Genomics Hum Genet. 7: 277-300, 2006. [Journal]

15) Gattis JL, Washington AV, Chisholm MM, Quigley L, Szyk A, McVicar DW, Lubkowski J.
The structure of the extracellular domain of triggering receptor expressed on myeloid cells like transcript-1 and evidence for a naturally occurring soluble fragment.
J. Biol. Chem. 281: 13396-403, 2006. [Journal]

16) Hiremath MM, Mikhael AI, Taylor LS, Musso T, McVicar DW.
Complex regulation of the Csk homologous kinase (Chk) by IL-4 family cytokines and IFN-γ in human peripheral blood monocytes.
Mol Immunol. in press,, 2004. [Journal]

17) Washington AV, McVicar DW.
Receptors involved in the regulation of murine NK cells.
Current protocols in immunology / edited by John E. Coligan ... [et al.]. Appendix 1: Appendix 1R, 2004. [Journal]

18) Mori T, Giomarelli B, McMahon J, Mcvicar D, Washington A, inventor; DHHS, assignee.
Isolation Of Human Anti-tlt-1 Antibody Fragments (single Chain Fvs) Recognizing Both Human And Murine Tlt-1 Extracellular Domain Of Phage Displayed Human Scfv Library With The Apparent Ablility To Suppress Thrombin-induced Platelet Aggregation In Vitro.
Patent Pending, Filed in 2006. Application No. 11/634,331. Pending [Patent]

19) O'Shea J, Leonard W, Johnston J, Russell S, McVicar D, Kawamura M, inventor.
Janus Family Kinases and Identification of Immune Modulators.
US Patent: 7,070,972 B1. . [Patent]

20) Washington AV, Schubert RL, Quigley L, Disipio T, Feltz R, Cho EH, McVicar DW.
TREM Family Member, TLT-1, Is Found Exclusively in the Alpha Granules of Megakaryocytes and Platelets.
Blood. in press, 2004. [Journal]

21) Haan S, Ferguson P, Sommer U, Hiremath M, McVicar DW, Heinrich PC, Johnston JA, Cacalano NA.
Tyrosine phosphorylation disrupts elongin interaction and accelerates SOCS3 degradation.
J Biol Chem. 278: 31972-9, 2003. [Journal]

22) Washington AV, Quigley L, McVicar DW.
Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster. Triggering receptors expressed on myeloid cells.
Blood. 100: 3822-4, 2002. [Journal]

23) McVicar DW, Winkler-Pickett R, Taylor LS, Makrigiannis A, Bennett M, Anderson SK, Ortaldo JR.
Aberrant DAP12 signaling in the 129 strain of mice: implications for the analysis of gene-targeted mice.
J Immunol. 169: 1721-8, 2002. [Journal]

24) Makrigiannis AP, Pau AT, Schwartzberg PL, McVicar DW, Beck TW, Anderson SK.
A BAC contig map of the Ly49 gene cluster in 129 mice reveals extensive differences in gene content relative to C57BL/6 mice.
Genomics. 79: 437-44, 2002. [Journal]

25) McFarland HI, Hansal SA, Morris DI, McVicar DW, Love PE, Rosenberg AS.
Signaling through MHC in transgenic mice generates a population of memory phenotype cytolytic cells that lack TCR.
Blood. 101: 4520-8, 2003. [Journal]

26) Washington AV, McVicar DW.
Receptors involved in the regulation of murine NK cells.
Current Protocol in Immunology. A.1R.1-A.1R.8, 2002. [Journal]

27) McVicar DW, Burshtyn DN.
Intracellular signaling by the killer immunoglobulin-like receptors and Ly49.
Sci STKE. 2001: RE1, 2001. [Journal]

28) Schaeffer EM, Yap GS, Lewis CM, Czar MJ, McVicar DW, Cheever AW, Sher A, Schwartzberg PL.
Mutation of Tec family kinases alters T helper cell differentiation.
Nat Immunol. 2: 1183-8, 2001. [Journal]

29) Anderson SK, Ortaldo JR, McVicar DW.
The ever-expanding Ly49 gene family: repertoire and signaling.
Immunol Rev. 181: 79-89, 2001. [Journal]

30) Mason LH, Willette-Brown J, Mason AT, McVicar D, Ortaldo JR.
Interaction of Ly-49D+ NK cells with H-2Dd target cells leads to Dap-12 phosphorylation and IFN-gamma secretion.
J Immunol. 164: 603-11, 2000. [Journal]

31) Paul SP, Taylor LS, Stansbury EK, McVicar DW.
Myeloid specific human CD33 is an inhibitory receptor with differential ITIM function in recruiting the phosphatases SHP-1 and SHP-2.
Blood. 96: 483-90, 2000. [Journal]

32) Taylor LS, Paul SP, McVicar DW.
Paired inhibitory and activating receptor signals.
Rev Immunogenet. 2: 204-19, 2000. [Journal]

33) Taylor GA, Collazo CM, Yap GS, Nguyen K, Gregorio TA, Taylor LS, Eagleson B, Secrest L, Southon EA, Reid SW, Tessarollo L, Bray M, McVicar DW, Komschlies KL, Young HA, Biron CA, Sher A, Vande Woude GF.
Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP.
Proc Natl Acad Sci U S A. 97: 751-5, 2000. [Journal]

34) Schaeffer EM, Broussard C, Debnath J, Anderson S, McVicar DW, Schwartzberg PL.
Tec family kinases modulate thresholds for thymocyte development and selection.
J Exp Med. 192: 987-1000, 2000. [Journal]

This page was last updated on 9/24/2008.