Il-23-From Structural Genomics To The Clinic And What We Learned Along The Way |
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| Launch in standalone player | |
| Air date: | Wednesday, April 15, 2009, 4:15:00 PM Time displayed is Eastern Time, Washington DC Local |
| Category: | Immunology |
| Runtime: | 75 minutes |
| NLM Title: | IL-23, from structural genomics to the clinic and what we learned along the way [electronic resource] / Rob Kastelein ; [Immunology Interest Group]. |
| Author: | Kastelein, Robert Adriaan. National Institutes of Health (U.S.). Immunology Interest Group. |
| Publisher: | [Bethesda, Md. : National Institutes of Health, 2009] |
| Abstract: | (CIT): Dr. Rob Kastelein has developed, aided by bioinformatics and biochemical tools, a research program aimed at the discovery of novel cytokines, growth factors, and receptors in various signal transduction pathways. The targeted signaling systems include the hematopoietic pathways and the IL-1/TLR pathways with the intended goal of studying complete systems rather than individual molecules. Based on early studies to elucidate principles of protein-protein recognition using the interaction of cytokines and their receptors as model systems, sensitive structure-based computational tools were developed to identify novel members in these pathways. Highlights of these investigations include the identification of the family of TLR's (TLR1-10), novel IL-1-related ligands and receptors, novel cytokines related to the IL-17 family and a number of novel hematopoietic cytokines and their receptors, including IL-27 and IL-23. For many of these, interesting biological roles have been uncovered by matching ligand to receptor. Elucidating the function of these novel molecules in human disease is currently the major focus on his research. |
| Subjects: | Adjuvants, Immunologic Crohn Disease Interleukin-23 Psoriasis |
| Publication Types: | Government Publications Lectures |
| Download: | Download
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| NLM Classification: | QW 568 |
| NLM ID: | 101503627 |
| CIT File ID: | 15033 |
| CIT Live ID: | 7455 |
| Permanent link: | http://videocast.nih.gov/launch.asp?15033 |