Making Sense of Missense Mutations in Human Breast Cancer Susceptibility Genes

Web Site: http://www.cancer.gov/cancertopics/factsheet/Risk/BRCA

References:

Kuznetsov SG, Liu P, Sharan SK. (2008) Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2. Nature Medicine,14(8):875-81

Yang Y, Swaminathan S, Martin BK, Sharan SK. (2003) Aberrant splicing induced by missense mutations in BRCA1: clues from a humanized mouse model. Human Molecular Genetics, 12(17):2121-31.

Materials Available From The Scientific Library

Viruses, microRNA and Cancer

Web Site: http://ccr.cancer.gov/staff/staff.asp?profileid=12674

References:

Searching for targets of viral microRNAs. Whitby, Denise. Nature Genetics. Jan 2009; 41(1): 7 - 8.

Conservation of Virally Encoded MicroRNAs in Kaposi Sarcoma–Associated Herpesvirus in Primary Effusion Lymphoma Cell Lines and in Patients with Kaposi Sarcoma or Multicentric Castleman Disease. Vickie Marshall, Thomas Parks, Rachel Bagni, Cheng Dian Wang, Mark A. Samols, Jianhong Hu, Kathleen M. Wyvil, Karen Aleman, Richard F. Little, Robert Yarchoan, Rolf Renne, and Denise Whitby. JID. March 2007:195.

Sphigolipids in Health and Disease

Web Site: http://ccr.cancer.gov/Staff/staff.asp?profileid=5574

References:

Sphingolipids and membrane biology as determined from genetic models. Rao RP, Acharya JK. Prostaglandins Other Lipid Mediat. 2008 Feb;85(1-2):1-16. Epub 2007 Oct 13.

Enzymes of sphingolipid metabolism in Drosophila melanogaster. Acharya U, Acharya JK. Cell Mol Life Sci. 2005 Jan;62(2):128-42. Hannun YA, Obeid LM.

Principles of bioactive lipid signalling: lessons from sphingolipids. Nat Rev Mol Cell Biol. 2008 Feb;9(2):139-50.

Bacillus anthracis: Early interactions with the host

Web Site: http://emedicine.medscape.com/article/212127-overview

References:

Cote, C. K., T. L. DiMezzo, D. J. Banks, K. A. Bradley, and S. L. Welkos. Early interactions between fully virulent Bacillus anthracis and macrophages that influence the balance between spore clearance and development of a lethal infection. 2008. Microbes and Infection. 10(6):613-619.

Cote, C. K., J. A. Bozue, K. L. Moody, T. L. DiMezzo, C. E. Chapman, and S. L. Welkos. Analysis of a novel spore antigen in Bacillus anthracis that contributes to spore opsonization. 2008. Microbiology. 154(2):619-632.

Bozue J, Moody KL, Cote CK, Stiles BG, Friedlander AM, Welkos SL, Hale ML. Bacillus anthracis spores of the bclA mutant exhibit increased adherence to epithelial cells, fibroblasts, and endothelial cells but not to macrophages Infection and Immunity. 75(9):4498-4505 Sep 2007.

Materials Available From The Scientific Library

Controlling expression of exogenously delivered genes to circumvent the immune response

References:

Immune Responses to Gene Product of Inducible Promoters. Caroline Le Guiner, Knut Stieger, Richard O. Snyder, Fabienne Rolling and Philippe Moullier. Current Gene Therapy, 2007, 7, 334-346.

Animal Models in Drug Development

NOTE: The date/time for this seminar has changed. The seminar will now be held on Wednesday 7/22 at 11:30am in Building 549 Auditorium.

Web Site:http://dtp.nci.nih.gov/branches/btb/btb_index.html

References:

Antitumor Efficacy Testing in Rodents. Melinda G. Hollingshead. JNCI. November 2008, Vol. 100, Issue 21.

Preclinical Modeling of a Phase 0 Clinical Trial: Qualification of a Pharmacodynamic Assay of Poly (ADP-Ribose) Polymerase in Tumor Biopsies of Mouse Xenografts. Robert J. Kinders, Melinda Hollingshead, Sonny Khin, Larry Rubinstein, Joseph E.Tomaszewski, James H. Doroshow, Ralph E. Parchment, and the National Cancer Institute Phase Clinical Trials Team. Clin Cancer Res. 2008;6877 14(21) November 1, 2008.

Materials Available From The Scientific Library

Therapeutic antibodies - the dream of magic bullets achieved?

Web Site:http://ccr.cancer.gov/staff/staff.asp?profileid=5749

References:

Dimitrov, D. S. and Marks, J. D.: Therapeutic antibodies: Current state and future trends - is a paradigm change coming soon? Methods Mol. Biol. 525:1-27, 2009

Chen W, Zhu Z, Feng Y, Dimitrov DS. Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers. Proc. Natl. Acad. Sci. U.S.A. 105(44): 17121-6, 2008.

Prabakaran P, Zhu Z, Xiao X, Biragyn A, Dimitrov AS, Broder CC, Dimitrov DS. Potent human monoclonal antibodies against SARS CoV, Nipah and Hendra viruses. Expert opinion on biological therapy. 9: 355-368, 2009

Quest for the Discovery of Antivirals to Treat Alphavirus Infections

Websites:
www.usamriid.army.mil
http://www.ncbi.nlm.nih.gov/ICTVdb/ICTVdB/00.073.0.01.026.htm
www.prosetta.com

References:

Lingappa VR and Lingappa JR. 2005. Recent insights into biological regulation from cell-free protein-synthesizing systems. Mt Sinai J Med. 72(3): 141-60. (free online)

Klein KC, Dellos SR, and Lingappa JR. 2005. Identification of residues in the hepatitis C virus core protein that are critical for capsid assembly in a cell-free system. J Virol. 79(11):6814-26.

Lingappa JR and Theilen, BK. 2009. Assembly of immature HIV-1 capsids using a cell-free system. Methods Mol Biol. 485:185-95.