[ F04B Roster ]
The F04B panel reviews fellowship applications covering structure and biophysical behavior and dynamics of biological macromolecules. This includes applications concerned with the structure-function relationships of proteins, nucleic acids, glycoproteins, lipid bilayers and membrane proteins; X-ray crystallography, multi-dimensional NMR, electron microscopy, circular dichroism, fluorescence, and computational methods; single molecule dynamics and interactions by fluorescence and microscopic techniques; and molecular interactions for defining and maintaining cellular shape and function. Specific areas covered by F04B include:
- Proteomics, global approaches to protein function, and posttranslational modification
- Computational data mining for analysis of proteins and related microarrays
- Physical chemistry of biological macromolecules, including conformation and structure of proteins and nucleic acids
- Spectroscopic methods, including multi-dimensional nuclear magnetic resonance, X-ray crystallography, Raman and FTIR
- Protein and nucleic acid folding and conformation by experimental and computational methods
- Thermodynamics of macromolecular interactions, including isothermal calorimetry
- Kinetic analyses, including pH or temperature jump methods
- Structure and physical chemistry of lipid bilayer membranes and related model systems
- Physical chemical instrumentation, including development of new approaches and application of computers to such instrumentation
- Indirect methods for structure and dynamics determinations, including fluorescence dye labeling and tethering
- Carbohydrate biochemistry and glycoproteins, including synthesis and processing
- Signal transduction at molecular or subcellular levels, including protein structure, function, and enzymology
- Extracellular matrix at molecular or subcellular levels
- Motility and cytoskeleton at molecular or subcellular levels
Fellowship panels with most closely related areas of similar science listed in rank order are:
Chemical and Bioanalytical Sciences [F04A] Cell Biology and Development [F05] Biochemical and Molecular Neuroscience [F03A] Biophysical and Physiological Neuroscience [F03B]
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