Ongoing Research and Research Directions

• Fold Recognition through Threading
  • New threading algorithms
  • Development of potential energy functions
    • Knowledge based
    • Physical chemistry based
  • Energy minimized protein structures
  • Pre-threading sequence profile
  • Supercomputer implementation
  • Internet Interface
  
  
• ab initio Folding Prediction
  • Genetic algorithm
    • Backbone structure prefolding classification
    • Algorithm development
    • Parallel implementation
  • Application of TRUST global optimization algorithm
  • Energy function development
  
  
• Integration of Threading, ab initio Folding, and Experimental Data
  • Refinement of structures predicted by threading
  • Using partial experimental data in predictions
  • Domain assembly
    • Domains predicted from threading
    • Domains obtained from experiments