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Sponsored by: |
University of Manitoba |
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Information provided by: | University of Manitoba |
ClinicalTrials.gov Identifier: | NCT00308594 |
The purpose of this study is to determine whether dexamethasone is effective in the treatment of pain and disability resulting from a compressed spinal nerve in the neck (cervical radiculopathy).
Condition | Intervention | Phase |
---|---|---|
Cervical Radiculopathy |
Drug: Dexamethasone |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Single Group Assignment, Efficacy Study |
Official Title: | Oral Dexamethasone for the Treatment of Cervical Radiculopathy: A Double Blinded, Randomized, Placebo Controlled Trial |
Estimated Enrollment: | 100 |
Study Start Date: | November 2006 |
Estimated Study Completion Date: | November 2008 |
Cervical radiculopathy is causes both short and long term pain and diability. The current proven treatments include pain killers or surgery if there if patients experience progressive weakness or signs or spinal cord compression. Observations in both animal models and humans indicate that there is an inflammatory component to it. Corticosteroids (such as dexamethasone)are potent anti-inflammatories which may benefit people suffering from this condition. There is some evidence to support neck injections of drug directly onto the nerve root. This mmethod of drug delivery has been implicated with some serious complications such as paralysis and stroke. Delivering these medications in a pill form may provide a similar benefit without some of the serious complications.
Ages Eligible for Study: | 18 Years to 60 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | B2006:027 |
Study First Received: | March 28, 2006 |
Last Updated: | March 21, 2007 |
ClinicalTrials.gov Identifier: | NCT00308594 |
Health Authority: | Canada: Health Canada |
cervical radiculopathy dexamethasone corticosteroid oral |
Dexamethasone Neuromuscular Diseases Peripheral Nervous System Diseases Radiculopathy Dexamethasone acetate |
Anti-Inflammatory Agents Antineoplastic Agents, Hormonal Antineoplastic Agents Nervous System Diseases Physiological Effects of Drugs Gastrointestinal Agents Hormones, Hormone Substitutes, and Hormone Antagonists Antiemetics |
Glucocorticoids Hormones Pharmacologic Actions Autonomic Agents Therapeutic Uses Peripheral Nervous System Agents Central Nervous System Agents |