Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsors and Collaborators: |
Rajavithi Hospital Clinical Molecular Biological Center,Department of Education and Research, Rajavithi hospital: Thailand |
---|---|
Information provided by: | Rajavithi Hospital |
ClinicalTrials.gov Identifier: | NCT00314080 |
Background. Northern Thailand's biggest botulism outbreak to date occurred on 14 March 2006 and affected 209 people. Of these, 42 developed respiratory failure, and 25 of those who developed respiratory failure were referred to 9 high facility hospitals for treatment of severe respiratory failure and autonomic nervous system involvement. Among these patients, we aimed to assess the relationship between the rate of ventilator dependence and the occurrence of treatment by day 4 versus day 6 after exposure to bamboo shoots (the source of the botulism outbreak), as well as the relationship between ventilator dependence and negative inspiratory pressure.
Methods. The investigators reviewed the circumstances and timing of symptoms following exposure. Mobile teams treated patients with botulinum antitoxin on day 4 or day 6 after exposure in Nan Hospital (Nan, Thailand). Eighteen patients (in 7 high facility hospitals) with severe respiratory failure received a low- and high-rate repetitive nerve stimulation test, and negative inspiratory pressure was measured.
Condition | Intervention |
---|---|
Respiratory Failure Botulism |
Drug: Botulinum AntiToxin Procedure: neuro-electrophysiologic study, repetitive nerve stimulation Procedure: Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure |
Study Type: | Observational |
Official Title: | An Outbreak of Botulism in Thailand: Clinical Manifestations and Management of Severe Respiratory Failure |
Ages Eligible for Study: | 1 Year and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusions:
Exclusion Criteria:
Thailand | |
Rajavithi Hospital | |
Bangkok, Thailand, 10400 |
Principal Investigator: | Subsai Kongsaengdao, M.D. | Rajavithi Hospital |
Study ID Numbers: | RVH_CER_001 |
Study First Received: | March 30, 2006 |
Last Updated: | October 23, 2008 |
ClinicalTrials.gov Identifier: | NCT00314080 |
Health Authority: | Thailand: Ministry of Public Health |
Botulism Botulinum anti-toxin Repetitive nerve stimulation Respiratory failure |
Bacterial Infections Antitoxins Neurotoxicity Syndromes Botulism Respiration Disorders Neurotoxicity syndromes Botulinum Antitoxin |
Poisoning Disorders of Environmental Origin Gram-Positive Bacterial Infections Respiratory Insufficiency Neuromuscular Diseases Respiratory Tract Diseases Clostridium Infections |
Immunologic Factors Physiological Effects of Drugs Food Poisoning |
Nervous System Diseases Neuromuscular Junction Diseases Pharmacologic Actions |