Cyclophosphamide and Prednisone With or Without Immunoglobulin in Treating Abnormal Muscle Movement in Children With Neuroblastoma
A total of 18-52 patients (9-26 per treatment arm) will be accrued for this
study within 2-5.8 years.
Efficacy as measured by assessment of response of opsoclonus, gait, neural, stance, arm and hand function at baseline, 2 months, 6 months, and 1 year
Response as measured by assessment of opsoclonus, gait, neural, stance, arm and hand function at baseline, 2 months, 6 months, and 1 year
Motor coordination as assessed by neurological examination and Vineland Adaptive Behavior Scale at baseline, 1 and 5 years
Functional outcome as assessed by age-appropriate neuropsychological testing at baseline, 1 and 5 years
Biology of neuroblastoma associated opsoclonus-myoclonus-ataxia syndrome, specifically by MRI findings, anti-neuronal antibodies, SCF findings and tumor biology at baseline, 6 months, and 1 year
Long-term prognosis for neurologic recovery by neurological examination at baseline, 1 and 5 years
Tumor outcome in terms of event-free survival and overall survival at 1, 5, and 10 years
This is a randomized, multicenter study. Patients are stratified
according to risk group per protocol COG-ANBL00B1 (low risk vs intermediate risk on
COG-A3961 vs high risk on COG-A3973).
Patients are followed during therapy every month for 6 months, at 1 year, and then annually
thereafter.
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U.S.A. |
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Arizona |
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Phoenix |
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| Phoenix Children's Hospital |
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| Jessica Boklan | |
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Tucson |
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| Arizona Cancer Center at University of Arizona Health Sciences Center |
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| Clinical Trials Office - Arizona Cancer Center at University of Arizona Health Sciences Center | |
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Arkansas |
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Little Rock |
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| Arkansas Cancer Research Center at University of Arkansas for Medical Sciences |
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| Clinical Trial Office - Arkansas Cancer Research Center at University of Arkansas for Medical Sciences | |
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California |
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Loma Linda |
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| Loma Linda University Cancer Institute at Loma Linda University Medical Center |
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| Clinical Trials Office - Loma Linda University Cancer Institute | |
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Los Angeles |
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| Samuel Oschin Comprehensive Cancer Institute at Cedars-Sinai Medical Center |
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| Carole Hurvitz | |
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Sacramento |
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| Kaiser Permanente Medical Center - Oakland |
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| Vincent Kiley | |
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San Diego |
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| Rady Children's Hospital - San Diego |
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| Clinical Trials Office - Rady Children's Hospital - San Diego | |
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San Francisco |
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| UCSF Helen Diller Family Comprehensive Cancer Center |
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| Clinical Trials Office - UCSF Helen Diller Family Comprehensive Cancer Center | |
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Colorado |
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Aurora |
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| Children's Hospital Center for Cancer and Blood Disorders |
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| Kelly Maloney | |
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Denver |
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| Presbyterian - St. Luke's Medical Center |
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| Clinical Trials Office - Presbyterian - St. Luke's Medical Center | |
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Delaware |
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Wilmington |
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| Alfred I. duPont Hospital for Children |
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| Clinical Trials Office - Alfred I. duPont Hospital for Children | |
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District of Columbia |
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Washington |
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| Children's National Medical Center |
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| Clinical Trials Office - Children's National Medical Center | |
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| Lombardi Comprehensive Cancer Center at Georgetown University Medical Center |
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| Clinical Trials Office - Lombardi Comprehensive Cancer Center | |
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Florida |
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Fort Myers |
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| Lee Cancer Care of Lee Memorial Health System |
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| Clinical Trials Office - Lee Cancer Care of Lee Memorial Health System | |
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Jacksonville |
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| Nemours Children's Clinic |
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| Eric Sandler | |
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Miami |
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| University of Miami Sylvester Comprehensive Cancer Center - Miami |
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| University of Miami Sylvester Comprehensive Cancer Center Clinical Trial Matching Service | |
| Email:
Sylvester@emergingmed.com |
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Pensacola |
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| Sacred Heart Cancer Center at Sacred Heart Hospital |
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| Clinical Trials Office - Sacred Heart Cancer Center | |
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St. Petersburg |
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| All Children's Hospital |
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| Gregory Hale | |
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Tampa |
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| St. Joseph's Cancer Institute at St. Joseph's Hospital |
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| Clinical Trials Office - St. Joseph's Cancer Institute | |
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West Palm Beach |
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| Kaplan Cancer Center at St. Mary's Medical Center |
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| Narayana Gowda | |
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Georgia |
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Atlanta |
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| Winship Cancer Institute of Emory University |
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| Howard Katzenstein | |
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| Howard Katzenstein | |
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Idaho |
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Boise |
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| Mountain States Tumor Institute at St. Luke's Regional Medical Center |
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| Eugenia Chang | |
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Illinois |
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Chicago |
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| Children's Memorial Hospital - Chicago |
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| Stewart Goldman | |
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| University of Chicago Cancer Research Center |
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| Clinical Trials Office - University of Chicago Cancer Research Center | |
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Peoria |
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| Saint Jude Midwest Affiliate |
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| Stephen Smith | |
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Indiana |
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Indianapolis |
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| Indiana University Melvin and Bren Simon Cancer Center |
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| Clinical Trials Office - Indiana University Cancer Center | |
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Kentucky |
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Lexington |
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| Lucille P. Markey Cancer Center at University of Kentucky |
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| Clinical Trials Office - Markey Cancer Center at University of Kentucky Chandler Medical Center | |
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Louisville |
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| Kosair Children's Hospital |
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| Clinical Trials Office - Kosair Children's Hospital | |
| Email:
CancerResource@nortonhealthcare.org |
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Louisiana |
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Alexandria |
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| Tulane Cancer Center Office of Clinical Research |
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| Clinical Trials Office - Tulane Cancer Center | |
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Maryland |
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Baltimore |
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| Alvin and Lois Lapidus Cancer Institute at Sinai Hospital |
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| Joseph Wiley | |
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Massachusetts |
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Boston |
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| Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute |
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| Suzanne Shusterman | |
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| Floating Hospital for Children at Tufts - New England Medical Center |
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| Cynthia Kretschmar | |
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| Massachusetts General Hospital |
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| Clinical Trials Office - Massachusetts General Hospital | |
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Michigan |
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Detroit |
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| Barbara Ann Karmanos Cancer Institute |
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| Clinical Trials Office - Barbara Ann Karmanos Cancer Institute | |
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Flint |
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| Hurley Medical Center |
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| Clinical Trials Office - Hurley Medical Center | |
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Grand Rapids |
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| Butterworth Hospital at Spectrum Health |
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| David Dickens | |
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Grosse Pointe Woods |
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| Van Elslander Cancer Center at St. John Hospital and Medical Center |
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| Clincial Trials Office - Van Elslander Cancer Center at St. John Hospital and Medical Center | |
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Lansing |
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| Breslin Cancer Center at Ingham Regional Medical Center |
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| Clinical Trials Office - Breslin Cancer Center at Ingham Regional Medical Center | |
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Minnesota |
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Minneapolis |
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| Masonic Cancer Center at University of Minnesota |
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| Clinical Trials Office - Masonic Cancer Center at University of Minnesota | |
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Mississippi |
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Jackson |
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| University of Mississippi Cancer Clinic |
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| Gail Megason | |
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Missouri |
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Kansas City |
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| Children's Mercy Hospital |
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| Maxine Hetherington | |
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Nevada |
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Las Vegas |
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| CCOP - Nevada Cancer Research Foundation |
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| Jonathan Bernstein | |
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| Jonathan Bernstein | |
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New Jersey |
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Hackensack |
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| Hackensack University Medical Center Cancer Center |
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| Clinical Trials Office - Hackensack University Medical Center Cancer Center | |
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Morristown |
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| Overlook Hospital |
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| Hazem Mahmoud | |
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Newark |
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| Newark Beth Israel Medical Center |
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| Clinical Trials Office - Newark Beth Israel Medical Center | |
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Paterson |
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| St. Joseph's Hospital and Medical Center |
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| Mary Ann Bonilla | |
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New York |
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Albany |
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| Albany Medical Center Hospital |
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| Vikramjit Kanwar | |
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New York |
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| Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center |
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| Clinical Trials Office - Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center | |
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Syracuse |
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| SUNY Upstate Medical University Hospital |
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| Clinical Trials Office - SUNY Upstate Medical University Hospital | |
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Valhalla |
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| New York Medical College |
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| Fevzi Ozkaynak | |
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North Carolina |
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Chapel Hill |
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| Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill |
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| Clinical Trials Office - Lineberger Comprehensive Cancer Center | Ph: | 877-668-0683; 919-966-4432 | | |
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Charlotte |
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| Blumenthal Cancer Center at Carolinas Medical Center |
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| Clinical Trials Office - Blumenthal Cancer Center at Carolinas Medical Center | |
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Durham |
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| Duke Comprehensive Cancer Center |
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| Clinical Trials Office - Duke Comprehensive Cancer Center | |
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Winston-Salem |
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| Wake Forest University Comprehensive Cancer Center |
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| Clinical Trials Office - Wake Forest University Comprehensive Cancer Center | |
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Ohio |
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Akron |
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| Akron Children's Hospital |
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| Clinical Trials Office - Akron Children's Hospital | |
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Columbus |
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| Nationwide Children's Hospital |
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| Amanda Termuhlen | |
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Dayton |
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| Children's Medical Center - Dayton |
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| Emmett Broxson | |
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Oklahoma |
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Oklahoma City |
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| Oklahoma University Cancer Institute |
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| Rene McNall-Knapp | |
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Oregon |
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Portland |
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| Legacy Emanuel Hospital and Health Center and Children's Hospital |
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| Clinical Trials Office - Legacy Emanuel Hospital and Health Center and Children's Hospital | |
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Pennsylvania |
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|
Hershey |
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| Penn State Cancer Institute at Milton S. Hershey Medical Center |
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| Clinical Trials Office - Penn State Cancer Institute at Milton S. Hershey Medical Center | |
| Email:
CTO@hmc.psu.edu |
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Philadelphia |
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| Children's Hospital of Philadelphia |
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| Richard Aplenc | |
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| St. Christopher's Hospital for Children |
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| Clinical Trials Office - St. Christopher's Hospital for Children | |
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Pittsburgh |
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| Children's Hospital of Pittsburgh |
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| Clinical Trials Office - Children's Hospital of Pittsburgh | |
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South Carolina |
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Greenville |
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| Greenville Hospital Cancer Center |
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| Clinical Trials Office - Greenville Hospital Cancer Center | |
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South Dakota |
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Sioux Falls |
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| Sanford Cancer Center at Sanford USD Medical Center |
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| Clinical Trials Office - Sanford Cancer Center | |
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Tennessee |
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Knoxville |
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| East Tennessee Children's Hospital |
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| Ray Pais | |
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Texas |
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Amarillo |
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| Texas Tech University Health Sciences Center School of Medicine - Amarillo |
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| Curtis Turner | |
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Corpus Christi |
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| Driscoll Children's Hospital |
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| Clinical Trials Office - Driscoll Children's Hospital | |
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Dallas |
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| Medical City Dallas Hospital |
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| Carl Lenarsky | |
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Fort Worth |
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| Cook Children's Medical Center - Fort Worth |
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| Clinical Trials Office - Cook's Children's Medical Center | |
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San Antonio |
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| Methodist Children's Hospital of South Texas |
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| Michael Grimley | |
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| University of Texas Health Science Center at San Antonio |
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| Paul Thomas | |
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Washington |
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Seattle |
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| Children's Hospital and Regional Medical Center - Seattle |
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| Julie Park | |
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Spokane |
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| Providence Cancer Center at Sacred Heart Medical Center |
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| Judy Felgenhauer | |
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West Virginia |
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Charleston |
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| West Virginia University Health Sciences Center - Charleston |
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| Allen Chauvenet | |
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Wisconsin |
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Milwaukee |
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| Midwest Children's Cancer Center at Children's Hospital of Wisconsin |
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| Bruce Camitta | |
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Australia |
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New South Wales |
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Westmead |
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| Westmead Institute for Cancer Research at Westmead Hospital |
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| Geoffrey McCowage | |
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Western Australia |
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Perth |
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| Princess Margaret Hospital for Children |
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| Catherine Cole | |
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Canada |
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British Columbia |
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Vancouver |
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|
|
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| Children's & Women's Hospital of British Columbia |
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| Mason Bond | |
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Nova Scotia |
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Halifax |
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|
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| IWK Health Centre |
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| Margaret Yhap | |
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Quebec |
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Montreal |
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|
|
| Hopital Sainte Justine |
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| Yvan Samson | |
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| Yvan Samson | |
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| Montreal Children's Hospital at McGill University Health Center |
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| Sharon Abish | |
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Saskatchewan |
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Saskatoon |
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| Saskatoon Cancer Centre at the University of Saskatchewan |
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| Kaiser Ali | |
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