The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

General Information

Added text to state that the incidence of Ewing family of tumors is approximately three per 1,000,000 per year and has remained unchanged for 30 years, and that approximately 25% of patients will have metastatic disease at diagnosis (cited Esiashvili et al. as reference 6 and level of evidence 3i).

Treatment Option Overview

Added text about a study that suggested that a lower dose of cyclophosphamide produced a similar event-free survival (EFS) compared with a higher dose of ifosfamide and identified a trend toward better EFS for patients with localized Ewing sarcoma when treatment included etoposide (cited Paulussen et al. as reference 17 and level of evidence 1iiA).

Added Navid et al. as reference 50 and level of evidence 3ii.

Ewing Tumor of Bone: Localized Tumors

Added text about a study that randomized patients to one of two regimens of chemotherapy for newly diagnosed Ewing sarcoma (cited Womer et al. as reference 14).

Ewing Tumor of Bone: Recurrent Tumors

This section was extensively revised.

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