Stage I Endometrial Cancer
Current Clinical Trials
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ editorial boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence 1 for more information.)
Standard treatment options:
If the tumor is well or moderately differentiated, involves the upper 66% of the corpus, has negative peritoneal cytology, is without vascular
space invasion, and has less than a 50% myometrial invasion, a total abdominal
hysterectomy and bilateral salpingo-oophorectomy should be done. Selected
pelvic lymph nodes may be removed. If they are negative, no postoperative
treatment is indicated. Postoperative treatment with a vaginal cylinder is
advocated by some clinicians.[1]
For all other cases and cell types, a periaortic and selective pelvic node
sampling should be combined with the total abdominal hysterectomy and bilateral
salpingo-oophorectomy, if there are no medical or technical contraindications.
One study found that node dissection per se did not significantly add to the
overall morbidity from hysterectomy.[2] While the radiation therapy will reduce the
incidence of local and regional recurrence, improved survival has not been
proven and toxic effects are worse.[3-6] Results
of two randomized trials on the use of adjuvant radiation therapy in patients with
stage I disease did not show improved survival but did show reduced locoregional recurrence (3%–4% vs. 12%–14% after 5–6 years' median follow-up, P < .001) with an increase in side effects.[6-8][Level of evidence: 1iiDii]
If the pelvic nodes are positive and the periaortic nodes are negative, total
pelvic radiation therapy, including the common iliac nodes, should be given. The
incidence of bowel complications is approximately 4%, and it can be even higher
if the radiation therapy is given after pelvic lymphadenectomy.[9] If the surgery is
done using a retroperitoneal approach, the toxic effects are lessened. If the
periaortic nodes are positive, the patient is a candidate for clinical trials
that could include radiation therapy and/or chemotherapy. Patients who have medical
contraindications to surgery should be treated with radiation therapy alone,
but inferior cure rates below those attained with surgery may occur.[1,10,11]
Current Clinical Trials
Check for U.S. clinical trials from NCI's PDQ Cancer Clinical Trials Registry that are now accepting patients with stage I endometrial carcinoma 2. The list of clinical trials can be further narrowed by location, drug, intervention, and other criteria.
General information about clinical trials is also available from the NCI Web site 3.
References
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Eltabbakh GH, Piver MS, Hempling RE, et al.: Excellent long-term survival and absence of vaginal recurrences in 332 patients with low-risk stage I endometrial adenocarcinoma treated with hysterectomy and vaginal brachytherapy without formal staging lymph node sampling: report of a prospective trial. Int J Radiat Oncol Biol Phys 38 (2): 373-80, 1997.
[PUBMED Abstract]
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Homesley HD, Kadar N, Barrett RJ, et al.: Selective pelvic and periaortic lymphadenectomy does not increase morbidity in surgical staging of endometrial carcinoma. Am J Obstet Gynecol 167 (5): 1225-30, 1992.
[PUBMED Abstract]
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Aalders J, Abeler V, Kolstad P, et al.: Postoperative external irradiation and prognostic parameters in stage I endometrial carcinoma: clinical and histopathologic study of 540 patients. Obstet Gynecol 56 (4): 419-27, 1980.
[PUBMED Abstract]
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Morrow CP, Bundy BN, Kurman RJ, et al.: Relationship between surgical-pathological risk factors and outcome in clinical stage I and II carcinoma of the endometrium: a Gynecologic Oncology Group study. Gynecol Oncol 40 (1): 55-65, 1991.
[PUBMED Abstract]
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Marchetti DL, Caglar H, Driscoll DL, et al.: Pelvic radiation in stage I endometrial adenocarcinoma with high-risk attributes. Gynecol Oncol 37 (1): 51-4, 1990.
[PUBMED Abstract]
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Creutzberg CL, van Putten WL, Koper PC, et al.: Surgery and postoperative radiotherapy versus surgery alone for patients with stage-1 endometrial carcinoma: multicentre randomised trial. PORTEC Study Group. Post Operative Radiation Therapy in Endometrial Carcinoma. Lancet 355 (9213): 1404-11, 2000.
[PUBMED Abstract]
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Keys HM, Roberts JA, Brunetto VL, et al.: A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 92 (3): 744-51, 2004.
[PUBMED Abstract]
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Scholten AN, van Putten WL, Beerman H, et al.: Postoperative radiotherapy for Stage 1 endometrial carcinoma: long-term outcome of the randomized PORTEC trial with central pathology review. Int J Radiat Oncol Biol Phys 63 (3): 834-8, 2005.
[PUBMED Abstract]
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Greven KM, Lanciano RM, Herbert SH, et al.: Analysis of complications in patients with endometrial carcinoma receiving adjuvant irradiation. Int J Radiat Oncol Biol Phys 21 (4): 919-23, 1991.
[PUBMED Abstract]
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Stokes S, Bedwinek J, Kao MS, et al.: Treatment of stage I adenocarcinoma of the endometrium by hysterectomy and adjuvant irradiation: a retrospective analysis of 304 patients. Int J Radiat Oncol Biol Phys 12 (3): 339-44, 1986.
[PUBMED Abstract]
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Grigsby PW, Kuske RR, Perez CA, et al.: Medically inoperable stage I adenocarcinoma of the endometrium treated with radiotherapy alone. Int J Radiat Oncol Biol Phys 13 (4): 483-8, 1987.
[PUBMED Abstract]
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