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recombinant vaccinia-CEA(6D)-TRICOM vaccine A vaccine consisting of recombinant vaccinia virus encoding the tumor-associated antigen carcinoembryonic antigen (CEA) and a TRIad of COstimulatory Molecules (B7-1, ICAM-1, and LFA-3; also called TRICOM). Vaccination with recombinant vaccinia-CEA(6D)-TRICOM vaccine stimulates the host immune system to mount a T-cell response against tumor cells expressing the CEA antigen. The use of TRICOM in the vaccine may elicit a greater antitumor cytotoxic T lymphocyte (CTL) immune response compared to the use of vaccinia-CEA alone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/web/20090509215207im_/http://www.cancer.gov/images/spacer.gif) | rV-CEA(6D)-TRICOM | | ![](https://webarchive.library.unt.edu/web/20090509215207im_/http://www.cancer.gov/images/spacer.gif) |
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