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biricodar dicitrate The dicitrate salt of a synthetic pipecolinate derivative with potential chemosensitizing activity. Biricodar binds directly to the plasma membrane drug-efflux pumps P-glycoprotein (Pgp) and multidrug resistance protein 1 (MRP-1) and inhibits their activities, which may result in increased intracellular accumulation and retention of cytotoxic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) | biricodar | | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) | Incel | | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) | VX-710 | | ![](https://webarchive.library.unt.edu/web/20090509164522im_/http://www.cancer.gov/images/spacer.gif) |
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