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Isoamyl acetate

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General Description
    Synonyms: Banana oil; Isopentyl alcohol, acetate; 3-Methyl-1-butanol acetate, 3-Methylbutyl ester of acetic acid, 3-Methylbutyl ethanoate

    OSHA IMIS Code Number: 1530

    Chemical Abstracts Service (CAS) Registry Number: 123-92-2

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: NS9800000

    Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1104 129 [27 KB, PDF]

    NIOSH Pocket Guide to Chemical Hazards, Isoamyl Acetate: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 100 ppm, 525 mg/m3 TWA

    OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 100 ppm, 525 mg/m3 TWA

    OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 100 ppm, 525 mg/m3 TWA

    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 50 ppm, 266 mg/m3 TWA; 100 ppm, 532 mg/m3 STEL (Listed under Pentyl acetate, All isomers)

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 100 ppm, 525 mg/m3 TWA
Health Factors
    NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 1000 ppm

    Potential symptoms: Irritation of eyes, skin, nose, throat; dermatitis; cough, sore throat; headache, drowsiness, weakness; eye redness, pain; dry skin; in animals: narcosis

    Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15); CNS effects (HE7)

    Affected organs: Eyes, skin, respiratory system, CNS

    Notes:
    1. Listed among FDA’s “food additives permitted for direct addition to food for human consumption” (21 CFR 172.515).
    2. Isoamyl acetate is used as a standard odorant in olfactory research and function testing, as well as in respirator fit testing (29 CFR 1910.134 Appendix A).

    Date Last Revised: 11/06/2006

    Literature Basis:
    • NIOSH Pocket Guide to Chemical Hazards: Isoamyl Acetate.
    • International Chemical Safety Cards (WHO/IPCS/ILO): Isoamyl acetate.
    • Bensafi, M., Rouby, C., Farget, V., Bertrand, B., Vigouroux, M. and Holley, A.: Autonomic nervous system responses to odours: the role of pleasantness and arousal. Chem. Senses 27(8): 703-709, 2002.
    • Grossmann, N., Brin, I., Aizenbud, D., Sichel, J.Y., Gross-Isseroff, R. and Steiner, J.: Nasal aikrflow and olfactory function after the repair of cleft palate (with and without cleft lip). Oral. Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 100(5): 539-544, 2005.
    • Pohanish, R.P. (editor): Isoamyl Acetate. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1319-1320.
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
      analytical solvent: (99:1) Carbon disulfide:dimethyl formamide
      maximum volume: 24 Liters   maximum flow rate: 0.1 L/min
      minimum time: 15 Minutes   maximum flow rate: 0.1 L/min
      current analytical method: Gas Chromatography; GC/FID
      method reference: OSHA Analytical Method (OSHA PV2142)
      method classification: Partially Validated


    • sampling media: Charcoal Tube (100/50 mg sections, 20/40 mesh)
      analytical solvent: Carbon disulfide
      maximum volume: 10 Liters   maximum flow rate: 0.2 L/min
      current analytical method: Gas Chromatography; GC/FID
      method reference: NIOSH Analytical Method (NIOSH 1450) [107 KB, PDF]
      method classification: Fully Validated
      note: Samples must be refrigerated for shipment to laboratory.

    On-Site Sampling Techniques/Methods:

    • device: Detector Tube
      manufacturer: Gastec
      model/type: 147
      sampling information: 4 minutes per pump stroke
      upper measurement limit: 200 ppm
      detection limit: 2 ppm
      overall uncertainty: 15% (10-50 ppm) 10% (50-200 ppm)
      method reference: # on-site air secondary (manufacturer)

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