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zosuquidar trihydrochloride A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/web/20090509222840im_/http://www.cancer.gov/images/spacer.gif) | LY335979 | | ![](https://webarchive.library.unt.edu/web/20090509222840im_/http://www.cancer.gov/images/spacer.gif) |
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