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phosphorodiamidate morpholino oligomer AVI-4126 A c-Myc antisense phosphorodiamidate morpholino oligomer (PMO) with potential antineoplastic activity. Phosphorodiamidate morpholino oligomer AVI-4126 binds to c-Myc mRNA and blocks its translation, which may result in the death of tumor cells overexpressing c-Myc. Differing from traditional antisense oligodeoxynucleotides (ODNs), neutrally charged PMOs are composed of subunits of nucleic acid bases linked to a synthetic backbone and, so, are less prone to enzymatic degradation. c-Myc, a proto-oncogene overexpressed in a variety of cancers, is involved in cellular proliferation, differentiation, and apoptosis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Abbreviation: | ![](https://webarchive.library.unt.edu/web/20090509193705im_/http://www.cancer.gov/images/spacer.gif) | PMO AVI-4126 | | ![](https://webarchive.library.unt.edu/web/20090509193705im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/web/20090509193705im_/http://www.cancer.gov/images/spacer.gif) | AVI-4126 | | ![](https://webarchive.library.unt.edu/web/20090509193705im_/http://www.cancer.gov/images/spacer.gif) |
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