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suramin A polysulphonated naphthylurea with potential antineoplastic activity. Suramin blocks the binding of various growth factors, including insulin-like growth factor I (IGF-I), epidermal growth factor (EGF), platelet-derived growth factor (PDGF), and tumor growth factor-beta (TGF-beta), to their receptors, thereby inhibiting endothelial cell proliferation and migration. This agent also inhibits vascular endothelial growth factor (VEGF)- and basic fibroblast growth factor (bFGF)-induced angiogenesis; retroviral reverse transcriptase; uncoupling of G-proteins from receptors; topoisomerases; cellular folate transport; and steroidogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonyms: | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) | Antrypol sodium suramin | | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) | Foreign brand names: | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) | 309 F Bayer 205 Fourneau 309 Germanin Moranyl Naganin Naganine | | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) | SUR | | ![](https://webarchive.library.unt.edu/web/20090509173418im_/http://www.cancer.gov/images/spacer.gif) |
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