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androstane steroid HE3235 An orally bioavailable adrenal steroid analogue with potential antineoplastic activity. Androstane steroid HE3235 appears to bind the androgen receptor (AR), down-regulating anti-apoptotic genes, such as Bcl-2, while increasing the expression of pro-apoptotic genes, such as caspases. In vitro and in vivo studies indicate that this agent
inhibits androstenediol-dependent LNCaP cell tumor growth. In addition, HE3235 may potentiate chemotherapeutic agents by down-regulating ABCG2, the gene encoding the multi-drug resistant (MDR) protein MDR2. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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US brand name: | ![](https://webarchive.library.unt.edu/web/20090509153057im_/http://www.cancer.gov/images/spacer.gif) | APOTONE | | ![](https://webarchive.library.unt.edu/web/20090509153057im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure name: | ![](https://webarchive.library.unt.edu/web/20090509153057im_/http://www.cancer.gov/images/spacer.gif) | 17alpha-ethynyl-5alpha-androstane-3alpha, 17beta-diol | | ![](https://webarchive.library.unt.edu/web/20090509153057im_/http://www.cancer.gov/images/spacer.gif) |
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