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recombinant tissue plasminogen activator A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, recombinant tPA increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) | t-PA | | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) | Activase | | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) | rt-PA | | ![](https://webarchive.library.unt.edu/web/20090509153343im_/http://www.cancer.gov/images/spacer.gif) |
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