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everolimus![Patient Information Patient Information](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/btn-patient-info.gif) A derivative of the natural macrocyclic lactone sirolimus with immunosuppressant and anti-angiogenic properties. In cells, everolimus binds to the immunophilin FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target of Rapamycin (mTOR), a key regulatory kinase. Inhibition of mTOR activation results in the inhibition of T lymphocyte activation and proliferation associated with antigen and cytokine (IL-2, IL-4, and IL-15) stimulation and the inhibition of antibody production. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) | 42-O-(2-hydroxy)ethyl rapamycin | | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) | US brand name: | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) | Afinitor | | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) | Code name: | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) | RAD001 | | ![](https://webarchive.library.unt.edu/web/20090509154217im_/http://www.cancer.gov/images/spacer.gif) |
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