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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Chemoprevention Study of Celecoxib in Patients With Familial Adenomatous Polyposis

Basic Trial Information

Phase	Type	Status	Age	Sponsor	Protocol IDs
No phase specified	Prevention	Active	16 and over	NCI	MDA-DM-02592 NCT00258219

Trial Description

Purpose:

Chemoprevention is the use of certain drugs to keep cancer from forming, growing, or coming back. The use of celecoxib may stop polyps from forming in patients with familial adenomatous polyposis.

This clinical trial is studying how well celecoxib works in treating patients with familial adenomatous polyposis.

Eligibility:

Eligibility criteria include the following:

• At least 16 years old
• At least 3 months since chemotherapy or radiation therapy
• No previous surgery to remove the entire colon and rectum
• No previous surgery to bypass the heart
• No previous surgery to open the arteries that bring blood flow to the heart
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will receive celecoxib by mouth twice a day for 6 months.

Patients will also undergo colonoscopy and a total of 23 biopsies of the colon and rectum once before and after treatment.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

M. D. Anderson Cancer Center at University of Texas

Imad Shureiqi, MD, MS, Protocol chair		Ph: 713-745-4929; 800-392-1611 Email: ishureiqi@mdanderson.org

U.S.A.
Texas
	Houston
	M. D. Anderson Cancer Center at University of Texas
		Clinical Trials Office - M. D. Anderson Cancer Center at the University of Texas	Ph:  713-792-3245

Registry Information
Official Title		Molecular Targeting of 15-LOX-1 for Apoptosis Induction in Human Colorectal Cancer
Trial Start Date		2002-11-06
Trial Completion Date		2010-12-01 (estimated)
Registered in ClinicalTrials.gov		NCT00258219
Date Submitted to PDQ		2005-07-20
Information Last Verified		2007-09-16
NCI Grant/Contract Number		CA160577, CA16672