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The Large-Scale Genome Sequencing Program
The Future of Genome Sequencing
Submit your comments on this white paper prepared for the planning process for the National Human Genome Research Institute.
Active Sequencing ProjectsThe Approved Sequencing Targets page contains a comprehensive listing of all NHGRI-sponsored large-scale sequencing projects in a sortable table. Information on Bacterial Artificial Chromosome resources can be found on the following pages:
How to Access Sequencing DataThe Large-Scale Sequencing Data Access and Release page contains information on policies and procedures for scientific researchers that would like to gain access to NHGRI-sponsored large-scale sequencing data. A separate set of Medical Sequencing Data Access policies and procedures has been developed due to the nature of human genomic data.
Process for Selecting New Sequencing TargetsPlease see the Target Selection page for detailed information on the process for selecting new sequencing targets.
Sequencing PoliciesAll major policies are reviewed by the National Advisory Council for Human Genome Research. General policies for data release were determined at a series of meetings of the genomics community. NHGRI is committed to the rapid release of all sequence data from community resource projects. All trace data are released rapidly (within a week) of their production into the public Trace Archive [ncbi.nlm.nih.gov]. Genome assemblies are released as soon as they have been validated. Specific technical policies for sequencing (for example, the quality standards for human and mouse sequence) are determined by the sequencing centers, together with the funding agencies. See Large-Scale Sequencing Policiesfor a description of the general Large-Scale Sequencing Program policies. Medical Sequencing policies (informed consent, data deposition, data access) are created with advice from the Medical Sequencing Working Group and additional outside advisors. Because human research participants are involved, access to some Medical Sequencing data is controlled. See Medical Sequencing Policies for a description of these policies.
Outside ResourcesThe NHGRI Large-Scale sequencing program sponsors several activities related to large-scale sequencing. One is the construction and distribution of BAC libraries. Another is the Human Genome Reference Consortium (HGRC), a collaborative effort between NHGRI, the National Center for Biotechnology Information (NCBI), the European Bioinformatics Institute (EBI), and the Wellcome Trust Sanger Institute (WTSI). The HGRC aims to maintain, update, and curate the human genome reference sequence. Currently Funded Sequencing Centers
Other Major Centers
Resources
Other
Program ContactsAdam Felsenfeld, Ph.D. (Medical Sequencing, Annotating the Human Genome, General Information)
Lu Wang, Ph.D. (Human Microbiome Project, Pathogens and Vectors, General Information) Brad Ozenberger, Ph.D. (Cancer Sequencing, The Cancer Genome Atlas) Kris Wetterstrand, M.S. (BAC Libraries) Jane Peterson, Ph.D. (Human Microbiome Project, General Information) AddressNational Human Genome Research Institute
Last Updated: April 29, 2009
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