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Interpreting Risk - The Impact of Life ExperiencesBackground:Approximately 5 percent to 10 percent of women with breast cancer have an inherited form of the disease. Scientists discovered several genes involved in breast cancer in the mid to late 1990's. Two such genes are BRCA1 and BRCA2. While every woman has a 13 percent lifetime risk of developing breast cancer, women with a mutation in one of those genes have significantly higher risk. At this time there is no cure for breast cancer. While some studies have suggested that there are medications and surgeries that may reduce a woman's risk of getting breast cancer, the results are indecisive. It is clear, however, that early diagnosis and treatment greatly improves a woman's chance for survival. Women who have close family members with breast or ovarian cancer (especially early–onset) or who are known to have genetic changes in one of the breast cancer genes are encouraged to have earlier and more frequent screening mammograms and clinical breast exams, in addition to performing breast self–exams. In this way, it is hoped that any evidence of breast cancer will be found early and result in early treatment and long–term survival. Vignette:Lisa and Tonya are college roommates. They agree on almost everything, but react very differently to an advertisement they saw in the local newspaper. A company was offering a blood test to screen for mutations in the BRCA1 and BRCA2 genes. Tonya's 44–year old mom was recently diagnosed with breast cancer. Fortunately, the disease was diagnosed early and successfully treated by removing the small lump from her breast. Tonya's mom is now feeling great and has fully recovered from the surgery. Lisa, on the other hand, has had a very different experience with the disease. When her mom was diagnosed with breast cancer at age 45, the cancer had already spread to other parts of her body. After two agonizing years of chemo- and radiation therapy, Lisa's mom died. It was a month before Lisa's high school graduation. Lisa desperately wants the genetic test. At this time, she feels convinced it will be just a matter of time before she will get breast cancer and die from it. She also says, that although she wants to have children some day, she won't if she is found to have one of the mutations in BRCA1 or BRCA2. She says she would rather adopt children than risk passing it on to her children. Tonya thinks the test is unnecessary. She says it costs too much and has heard how hard it is to get health insurance if you don't 'pass' a genetic test. Tonya believes that having a genetic test is just not worth the risks involved. She decides she will do self breast–exams regularly, since that is how her mom initially found her lump. She will also start having regular mammograms sometime in her 20s. She feels that while she may one day get breast cancer, she will catch it early and do as well as her mother did. Discussion Questions
Posted: April 2007 |
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