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Chemical Sampling Information |
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| Isophorone |
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General Description
Synonyms: Isoacetophorone; 3,5,5-Trimethyl-2-cyclohexene-1-one; 3,5,5-Trimethyl-2-cyclohexenone; 3,5,5-Trimethyl-2-cyclo-hexen-1-one
OSHA IMIS Code Number: 1538
Chemical Abstracts Service (CAS) Registry Number: 78-59-1
NIOSH, Registry of Toxic Effects (RTECS) Identification Number: GW7700000
Department of Transportation Regulation Number (49 CFR 172.101) and Guide: 1993 128 [27 KB PDF] (combustible liquid, n.o.s.)
NIOSH Pocket Guide to Chemical Hazards, Isophorone: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
OSHA Permissible Exposure Limit (PEL) for General Industry: 29 CFR 1910.1000 Z-1 Table -- 25 ppm, 140 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Construction Industry: 29 CFR 1926.55 Appendix A -- 25 ppm, 140 mg/m3 TWA
OSHA Permissible Exposure Limit (PEL) for Maritime: 29 CFR 1915.1000 Table Z-Shipyards -- 25 ppm, 140 mg/m3 TWA
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 ppm, 28 mg/m3 Ceiling; Appendix A3 - Confirmed Animal Carcinogen with Unknown Relevance to Humans
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 4 ppm, 23 mg/m3 TWA
Health Factors
Environmental Protection Agency (EPA) carcinogenic classification: Group C, possible human carcinogen
NIOSH Immediately Dangerous To Life or Health Concentration (IDLH): 200 ppm
Potential symptoms: Irritation of eyes, nose, throat; cough, sore throat; shortness of breath; headache, nausea, dizziness, lassitude (weakness, exhaustion); malaise (vague feeling of discomfort), narcosis; blurred vision; dry, cracking skin, dermatitis; in animals: kidney, liver damage.
Health Effects: Irritation-Eye, Nose, Throat, Skin---Marked (HE14); Acute CNS effects (HE4).
Affected organs: Eyes, skin, respiratory system, CNS, liver, kidneys
Notes:
- Above 84ºC, explosive vapor/air mixtures may be formed.
- EPA’s oral reference dose (daily oral exposure likely to be without an appreciable risk of deleterious effects during a lifetime) for isophorone is 0.2 mg/kg/day, and EPA’s provisional reference concentration is 12 µg/m3.
- The concentration of isophorone causing a 50% decrease in the respiratory rate of mice (a measure of sensory irritation) was reported to be 27.8 ppm.
Date Last Revised: 06/29/2006
Literature Basis:
- NIOSH Pocket Guide to Chemical Hazards: Isophorone.
- International Chemical Safety Cards (WHO/IPCS/ILO): Isophorone.
- EPA Air Toxics Website: Isophorone. U.S. Environmental Protection Agency Technology Transfer Network.
- De Ceaurriz, J., Micillino, J.C., Bonnet, P. and Guenier, J.P.: Sensory irritation caused by various industrial airborne chemicals. Toxicol Lett. 9(2): 137-143, 1981.
- Pohanish, R.P. (editor): Isophorone. In, Sittig’s Handbook of Toxic and Hazardous Chemicals and Carcinogens, Fourth Ed., Vol. 2. Norwich, NY: Noyes Publications, William Andrew Publishing, 2002, pp. 1342-1344.
Monitoring Methods used by OSHA
Laboratory Sampling/Analytical Method:
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sampling media: Petroleum Base Charcoal Tube (100/50 mg sections, 20/40 mesh)
analytical solvent: Carbon Disulfide
alternate analytical solvent: (99:1) Carbon Disulfide:Dimethylformamide
maximum volume: 12 Liters maximum flow rate: 0.2 L/min
current analytical method: Gas Chromatography; GC/FID
method reference: NIOSH Analytical Method (NIOSH 2508) [20 KB, PDF]
method classification: Fully Validated
note: The flowrate was dropped to 0.2 L/min on May 11, 1995 since in the 4th edition of NIOSH methods it states that the breakthrough was performed at 0.19 L/min but no data is given for 1 L/min.
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