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Caprolactam (Vapor)

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General Description
    Synonyms: Aminocaproic lactam; epsilon-Caprolactam; Hexahydro-2H-azepin-2-one; 2-Oxohexamethyleneimine

    OSHA IMIS Code Number: 0524

    Chemical Abstracts Service (CAS) Registry Number: 105-60-2

    NIOSH, Registry of Toxic Effects (RTECS) Identification Number: CM3675000

    NIOSH Pocket Guide to Chemical Hazards, Caprolactam: chemical description, physical properties, potentially hazardous incompatibilities, and more
Exposure Limits
    American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value (TLV): 5 mg/m3 TWA, Inhalable Fraction and Vapor (see TLV Booklet); Appendix A5 - Not Suspected as a Human Carcinogen

    National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Limit (REL): 0.22 ppm, 1 mg/m3 TWA; 0.66 ppm, 3 mg/m3 STEL
Health Factors
    International Agency for Research on Cancer (IARC) carcinogenic classification: Group 4 - Probably Not Carcinogenic to Humans [381 KB, PDF]

    Environmental Protection Agency (EPA) carcinogenic classification: Not classified

    Symptoms: Acute (short-term) exposure may result in irritation and burning of the eyes, nose, throat, and skin. Headaches, malaise, confusion, and nervous irritation after inhalation. Chronic (long-term) exposure may cause peeling of the hands and some eye, nose, and throat irritation.

    Health Effects: Irritation-Eye, Nose, Throat, Skin---Moderate (HE15) CNS Effects (HE7)

    Affected organs: Eyes, nose, throat, skin, CNS

    Literature Basis:
Monitoring Methods used by OSHA
    Laboratory Sampling/Analytical Method:

    • sampling media: OSHA Versatile Sampler (OVS-7) - 13 mm XAD-7 tube (270/140 mg sections, 20/60 mesh) with Glass Fiber Filter enclosed
      maximum volume: 100 Liters   maximum flow rate: 1.0 L/min (TWA)
      current analytical method: High Performance Liquid Chromatography; HPLC/UV
      method reference: OSHA Analytical Method (OSHA PV2012)
      method classification: Partially Validated

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